Nuclear power continues to be a safe, reliable, and carbon-free electricity generating source for the United States, though the cost of operating and maintaining the current United States nuclear power plant fleet has become uncompetitive with other sources. This gap is attributed to the advent of new digital instrumentation and control technologies that other electricity generating industries are currently leveraging to streamline work and greatly reduce operating, maintenance, and support costs. Digital instrumentation and control systems and control room modernization offers significant opportunities to reduce operating and maintenance costs to ensure the continued operation of the existing United States light-water reactors.These capabilities enable going beyond like-for-like replacement by offering new ways to transform current work processes through features like increased levels of automation, data analytics and visualization, and decision support. To ensure that the capabilities of the technology and people are being leveraged for safety and reliability, human and technology integration is an important consideration for any major digital main control room modification. This report presents interim findings of two key collaborations with United States utilities currently planning and executing large-scale digital instrumentation and control modifications to their main control rooms. While these collaborations are ongoing, this report presents lessons learned in the demonstration of the human and technology integration methodology.As this work continues, additional lessons learned will be developed. Collectively, this guidance provides industry with human and technology integration and human factors engineering guidance that reduces the technical, financial, and regulatory risk of upgrading the aging instrumentation and control systems to support extended plant life up to and beyond 60 years.