Example of the concentration dependence of elution order in the resolution of enantiomers on microcrystalline triacetylcellulose chiral stationary phase

Effects of solvent on chiral and enantiomeric separation of Koga bases using derivatized amylose chiral stationary phase

“…S,S-, meso-, and R,R-Koga base were synthesized in house according to Roussel et al 7 and Frizzle et al 10 Eluants were used as dilution solvent to prepare the sample at appropriate concentration.…”

“…At the supramolecular level, the lammelar arrangement of the polysaccharide chains provides a multitude of structurally different cavities. [6][7][8][9] These cavities result in multiple interaction sites, each exhibiting different discriminating properties. Some of the adsorption sites are readily accessible and the adsorption/desorption process is dynamic.…”

Chiral Discrimination Study for Polysaccharide‐Based Chiral Stationary Phases

“…These have stemmed mainly from studies in the dominant normal-phase mode. Commonly encountered and unexplained abnormal effects, such as different organic modifiers, temperatures, additives, and so on, caused a great deal of bewilderment; this significantly hindered systematic chiral method development [15][16][17][18][19][20][21][22][23][24][25].…”

Analytical and semipreparative separation of the enantiomers of new acetylcholinesterase inhibitors by high-performance liquid chromatography

“…The Chiralcel OD column shows particularly interesting and excellent resolving ability for a variety of racemic compounds, including many chiral drugs. The chiral recognition mechanism of these CSPs is, however, highly complex and difficult to model because the discriminating sites are multiple and competitive [12,13].…”