We say that two abelian varieties A and A ′ defined over a field F are polyquadratic twists if they are isogenous over a Galois extension of F whose Galois group has exponent dividing 2. Let A and A ′ be abelian varieties defined over a number field K of dimension g 1. In this article we prove that, if g 2, then A and A ′ are polyquadratic twists if and only if for almost all primes p of K their reductions modulo p are polyquadratic twists. We exhibit a counterexample to this local-global principle for g = 3. This work builds on a geometric analogue by Khare and Larsen, and on a similar criterion for quadratic twists established by Fité, relying itself on the works by Rajan and Ramakrishnan.