Excellent Activity of Newer Quinolones on Legionella pneumophila in J774 Macrophages

Comparative activity of quinolones, macrolides and ketolides against Legionella species using in vitro broth dilution and intracellular susceptibility testing

“…Various meth- ods have been utilized to address the intracellular location of Legionella. These include in vivo animal studies using guinea pigs and in vitro cell culture models using explanted guinea pig macrophages or human macrophage-like cell lines (U937, THP-1, Mono Mac 6, J774 and HL-60) [13][14][15][16][17][18][19].…”

Efficacy of Antibiotics Against Periodontopathogenic Bacteria Within Epithelial Cells: An In Vitro Study

“…Also, in the other cell systems and in macrophages, quinolones showed a good effectiveness against Legionella sp. 31 Interestingly, the efficacy of ciprofloxacin, another quinolone-type antibiotic, on intracellular gonococci was better than that of cefixime despite the same extracellular activity. 32 From results of this study, it is apparent that complete killing of all intracellular bacteria cannot be expected after a systemic application of antibiotics.…”

Fluoroquinolones vs Macrolides in the Treatment of Legionnaires Disease

“…Fluoroquinolones achieve high intracellular levels and have a lower minimum inhibitory concentration (MIC) against Legionella than erythromycin. 9,10 Moreover, experimental studies [11][12][13][14] have demonstrated that these antibiotics irreversibly inhibit the multiplication of this microorganism at an intracellular level. Some clinical observations 15,16 have shown great efficacy with fluoroquinolones in the treatment of this infection, particularly in severe illness or immunosuppressed patients.…”