Exceptional Long-Term Survival of an Elderly Patient With Metastatic Small Cell Neuroendocrine Carcinoma of the Cervix – A Case Report

Abstract

Small cell neuroendocrine cervical carcinoma (SCCC) is known for its aggressive nature and poor prognosis. There are no standard treatments so small cell lung cancer treatments are often referenced due to their similar morphology. Typical treatment options include a combination of external beam radiotherapy and brachytherapy for localised disease and palliative chemotherapy for advanced disease. The 5-year survival rate for patients presenting with advanced disease is dismal, around 0–14%. Here, we report a case of a 75-year-old woman who was diagnosed with small cell neuroendocrine cervical carcinoma (SCCC) in 2015. She presented with locally advanced SCCC with vaginal involvement, as well as solitary lung and peripancreatic metastases. She was treated with a combination of chemotherapy, chemoradiation and stereotactic radiotherapy, followed by maintenance etoposide, and achieved a very long-term survival. The patient continues to survive today.