Exceptional Renal Metastasis from Adenoid Cystic Carcinoma of the Nasal Cavity and Literature Review

Abstract

Adenoid cystic carcinoma (ACC) is a rare malignant cancer that arises from secretory glands. Slow growth, perineural invasion, and late recurrences are the main characteristics of ACC. Only few cases of kidney metastases from ACC have been reported in the literature. We report here the case of a 66-year-old female patient who presented with bilateral renal metastases from ACC of the nasal cavity, detected 14 years after treatment of primary tumor and 6 years after metastasectomy of lung metastases. Histological examination confirmed diagnosis and the patient was treated with systemic chemotherapy. Radiological evaluation showed stability of the disease. However, a progression with occurrence of metastases in other sites (lung and bones) has been observed after 7 months. She is still receiving second-line chemotherapy. To the best of our knowledge, this is the second case of kidney metastases from ACC of the nasal cavity.

A curious case of metastatic parotid adenoid cystic carcinoma to kidney

“…Maissa et al have suggested systemic chemotherapy agents such as cyclophosphamide, cisplatin, 5-fluorouracil and doxorubicin may have some efficacy against metastatic ACCs; however, chemotherapeutic management of renal metastases remains not well defined at present 30. Other treatment approaches such as thermoablation and renal embolisation have been proposed by Longo et al , predominantly from a palliative point of view and for the management of painful lesions 31…”