Excess all-cause and influenza-attributable mortality in Europe, December 2016 to February 2017

Vestergaard, Lasse S; Nielsen, Jens; Krause, Tyra Grove; Espenhain, Laura; Tersago, Katrien; Sierra, Natalia Bustos; Denissov, Gleb; Innos, Kaire; Virtanen, Mikko; Fouillet, Anne; Lytras, Theodore; Páldy, Anna; Bobvos, János; Domegan, Lisa; O’Donnell, Joan; Scortichini, Matteo; Martino, Ardigò; England, Kathleen; Calleja, Neville; Asten, Liselotte van; Teirlinck, Anne; Tønnessen, Ragnhild; White, Richard A.; Silva, Susana Pereira; Rodrigues, Ana Paula; Larrauri, Amparo; León-Gómez, Inmaculada; Ahmed, Farah; Junker, Christoph; Sinnathamby, Mary; Pebody, Richard; Reynolds, Arlene; Bishop, Jennifer; Gross, Diane; Adlhoch, Cornelia; Penttinen, Pasi; Mølbak, Kåre

doi:10.2807/1560-7917.es.2017.22.14.30506

Cited by 110 publications

(102 citation statements)

References 17 publications

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“…The number of fatal cases found in our study is therefore lower than previous Norwegian estimates . Also, individual‐based methods are found to underestimate influenza mortality, and models using all‐cause mortality in combination with influenza data are used in many European countries to make better estimations on total influenza‐related mortality . Patients dying from exacerbations of chronic disease or other complications after an influenza infection may not be registered as influenza‐related death.…”

Section: Discussioncontrasting

confidence: 66%

Burden of medically attended influenza in Norway 2008‐2017

Hauge

Bakken

Blasio

et al. 2019

Influenza Resp Viruses

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Background The burden of influenza in Norway remains uncertain, and data on seasonal variations and differences by age groups are needed. Objective To describe number of patients diagnosed with influenza in Norway each season and the number treated in primary or specialist health care by age. Further, to compare the burden of seasonal influenza with the 2009‐2010 pandemic outbreak. Methods We used Norwegian national health registries and identified all patients diagnosed with influenza from 2008 to 2017. We calculated seasonal rates, compared hospitalized patients with patients in primary care and compared seasonal influenza with the 2009‐2010 pandemic outbreak. Results Each season, on average 1.7% of the population were diagnosed with influenza in primary care, the average rate of hospitalization was 48 per 100 000 population while the average number of hospitalized patients each season was nearly 2500. The number of hospitalized influenza patients ranged from 579 in 2008‐2009 to 4973 in 2016‐2017. Rates in primary care were highest among young adults while hospitalization rates were highest in patients 80 years and older and in children below 5 years. The majority of in‐hospital deaths were in patients 70 years and older. Fewer patients were hospitalized during the 2009‐2010 pandemic than in seasonal outbreaks, but during the pandemic, more people in the younger age groups were hospitalized and fatal cases were younger. Conclusion Influenza causes a substantial burden in primary care and hospitals. In non‐pandemic seasons, people above 80 years have the highest risk of influenza hospitalization and death.

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Section: Discussioncontrasting

confidence: 66%

Burden of medically attended influenza in Norway 2008‐2017

Hauge

Bakken

Blasio

et al. 2019

Influenza Resp Viruses

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“…Viral epidemiology studies suggest that circulation of influenza virus, in particular with the virus type A subtype H3N2, is the main seasonal driver of excess mortality among the elderly [24]. This has been shown in the United States [25] and recently confirmed in Europe [26]. Our observation would suggest that lack of exercise can be consider as a risk factor in elderly during H3N2 endemic winter season.…”

Section: Discussionsupporting

confidence: 64%

Influenza vaccine response in community-dwelling German prefrail and frail individuals

et al. 2017

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BackgroundThe age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest of morbidity and mortality due to infection. Recently, significantly reduced anti-influenza antibody titers and increased rates of influenza infection after vaccination were reported in community-dwelling American frail older adults. The aim of our study was to further assess the relative impact of frailty and of each individual Fried frailty criterion on influenza vaccine response. Prefrail and frail community-dwelling German persons aged ≥70 years were recruited for a nutritional randomized double-blind placebo-controlled clinical trial conducted during the 2014–2015 influenza season. Herein, we present a sub-analysis study of the placebo group to compare 76 prefrail and frail participants.ResultsPrevious seasonal influenza vaccination rate was relatively high (77.6%) in the 76 volunteers aged from 70 to 93 years. Of these participants, 65.8% were diagnosed as prefrail and 34.2% as frail according to the Fried frailty criteria. In both prefrail and frail groups, elevated levels of pre-vaccination seroprotection were observed to all vaccine strains (H1N1: 54% and 32%, H3N2: 60% and 72%, B: 10% and 16%). Post-vaccination, similar increases in haemagglutination-inhibiting antibody titers were observed for the three vaccine strains in both prefrail and frail groups. No significant difference in geometric mean titer (GMT) ratios and in rates of seroconversion or seroprotection were observed between prefrail and frail groups. Regarding the five Fried frailty criteria, only participants with low physical activity had significantly lower GMT to the strains H3N2 (55.4 vs 103.7, p = 0.001) and B (13.9 vs 20.0, p = 0.06), as compared to those having normal physical activity.ConclusionsInfluenza vaccine response was not significantly affected by the frail phenotype, as defined by Fried frailty criteria, in community-dwelling German individuals. However, low physical activity may be a relevant predictor of lower serological response in vaccinated older individuals.Trial registration Clinicaltrials.gov NCT02262091 (October 8, 2013).

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“…The number of deaths was significantly associated with influenza A(H3N2)positive ARIs residents. This result was not surprising, as the circulation of influenza virus, in particular subtype A(H3N2), has been shown to be the main seasonal driver of excess mortality, particularly among the elderly (≥65 years of age) [32,33].…”

Section: Discussionmentioning

confidence: 97%

Epidemiology of Respiratory Pathogens among Elderly Nursing Home Residents with Acute Respiratory Infections in Corsica, France, 2013–2017

Masse

Capai

Falchi

2017

BioMed Research International

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Background The current study aims to describe the demographical and clinical characteristics of elderly nursing home (NH) residents with acute respiratory infections (ARIs) during four winter seasons (2013/2014–2016/2017), as well as the microbiological etiology of these infections. Methods Seventeen NHs with at least one ARI resident in Corsica, France, were included. An ARI resident was defined as a resident developing a sudden onset of any constitutional symptoms in addition to any respiratory signs. Nasopharyngeal swabs from ARI residents were screened for the presence of 21 respiratory agents, including seasonal influenza viruses. Results Of the 107 ARI residents enrolled from NHs, 61 (57%) were positive for at least one of the 21 respiratory pathogens. Forty-one (38.3%) of the 107 ARI residents had influenza: 38 (92%) were positive for influenza A (100% A(H3N2)) and three (8%) for influenza B/Victoria. Axillary fever (≥38°C) was significantly more common among patients infected with influenza A(H3N2). Conclusion The circulation of seasonal respiratory viruses other than influenza A(H3N2) seems to be sporadic among elderly NH residents. Investigating the circulation of respiratory viruses in nonwinter seasons seems to be important in order to understand better the dynamic of their year-round circulation in NHs.

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Excess all-cause and influenza-attributable mortality in Europe, December 2016 to February 2017

Cited by 110 publications

References 17 publications

Burden of medically attended influenza in Norway 2008‐2017

Burden of medically attended influenza in Norway 2008‐2017

Influenza vaccine response in community-dwelling German prefrail and frail individuals

Epidemiology of Respiratory Pathogens among Elderly Nursing Home Residents with Acute Respiratory Infections in Corsica, France, 2013–2017

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