Excess body weight is an independent risk factor for severe forms of COVID-19

Pietri, Léa; Giorgi, Roch; Bégu, Audrey; Lojou, Manon; Koubi, Marie; Cauchois, R.; Grangeot, Rachel; Dubois, Nicole; Kaplanski, Gilles; Valéro, René; Béliard, Sophie

doi:10.1016/j.metabol.2021.154703

Cited by 29 publications

(27 citation statements)

References 20 publications

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“…These factors were associated with a greater risk of developing critical or fatal conditions (2,19). Obesity was also soon recognized as an independent risk factor associated with worse outcomes (20,21). The United Kingdom was the first to reveal in March 2020, through a report from the Intensive Care National Audit and Research Centre (ICNARC), that twothirds of patients who developed serious or fatal complications following infection were overweight or obese.…”

Section: Obesity: a Risk Factor For Bad Covid-19 Outcomesmentioning

confidence: 99%

COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury

Lasbleiz

Gaborit

Soghomonian³

et al. 2021

Front. Endocrinol.

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In March 2020, the WHO declared coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a global pandemic. Obesity was soon identified as a risk factor for poor prognosis, with an increased risk of intensive care admissions and mechanical ventilation, but also of adverse cardiovascular events. Obesity is associated with adipose tissue, chronic low-grade inflammation, and immune dysregulation with hypertrophy and hyperplasia of adipocytes and overexpression of pro-inflammatory cytokines. However, to implement appropriate therapeutic strategies, exact mechanisms must be clarified. The role of white visceral adipose tissue, increased in individuals with obesity, seems important, as a viral reservoir for SARS-CoV-2 via angiotensin-converting enzyme 2 (ACE2) receptors. After infection of host cells, the activation of pro-inflammatory cytokines creates a setting conducive to the “cytokine storm” and macrophage activation syndrome associated with progression to acute respiratory distress syndrome. In obesity, systemic viral spread, entry, and prolonged viral shedding in already inflamed adipose tissue may spur immune responses and subsequent amplification of a cytokine cascade, causing worse outcomes. More precisely, visceral adipose tissue, more than subcutaneous fat, could predict intensive care admission; and lower density of epicardial adipose tissue (EAT) could be associated with worse outcome. EAT, an ectopic adipose tissue that surrounds the myocardium, could fuel COVID-19-induced cardiac injury and myocarditis, and extensive pneumopathy, by strong expression of inflammatory mediators that could diffuse paracrinally through the vascular wall. The purpose of this review is to ascertain what mechanisms may be involved in unfavorable prognosis among COVID-19 patients with obesity, especially cardiovascular events, emphasizing the harmful role of excess ectopic adipose tissue, particularly EAT.

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Section: Obesity: a Risk Factor For Bad Covid-19 Outcomesmentioning

confidence: 99%

COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury

Lasbleiz

Gaborit

Soghomonian³

et al. 2021

Front. Endocrinol.

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“…Recent studies suggest that obesity might be associated with a higher risk of developing severe COVID-19 respiratory disease [8][9][10][11][12][13][14][15][16]. A population-based analysis of a large UK biobank even suggests a dose-response relationship between the risk of severe COVID-19 disease and increasing BMI, waist circumference, or waist-to-hip ratio [8].…”

Section: Introductionmentioning

confidence: 99%

Association between obesity and hospital mortality in critical COVID-19: a retrospective cohort study

et al. 2021

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Background The impact of obesity on outcomes in acute respiratory distress syndrome (ARDS) is not well understood and remains controversial. Recent studies suggest that obesity might be associated with higher morbidity and mortality in respiratory disease caused by SARS-CoV-2 (COVID-19 disease). Our objective was to evaluate the association between obesity and hospital mortality in critical COVID-19 patients. Methods We conducted a retrospective cohort study in a tertiary academic center located in Montréal between March and August 2020. We included all consecutive adult patients admitted to the ICU for COVID-19-confirmed respiratory disease. Our main outcome was hospital mortality. We estimated the association between obesity, using the body mass index as a continuous variable, and hospital survival by fitting a multivariable Cox proportional hazards model. Results We included 94 patients. Median [q1, q3] body mass index (BMI) was 29 [26–32] kg/m 2 and 37% of patients were obese (defined as BMI > 30 kg/m 2 ). Hospital mortality for the entire cohort was 33%. BMI was significantly associated with hospital mortality (hazard ratio [HR] = 2.49 per 10 units BMI; 95% CI, from 1.69 to 3.70; p < 0.001) even after adjustment for sex, age and obesity-related comorbidities (adjusted HR = 3.50; 95% CI from 2.03 to 6.02; p < 0.001). Conclusions Obesity was prevalent in hospitalized patients with critical illness secondary to COVID-19 disease and a higher BMI was associated with higher hospital mortality. Further studies are needed to validate this association and to better understand its underlying mechanisms.

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“…Obesity (BMI > 30 kg/m 2 ) was connected with a significantly increased risk of critical COVID-19 and mortality [85]. Excess body weight multipliesthe risk of serious events connected to COVID-19 by 5.6 [86]. Dose-response meta-analysis indicates an increase of 5% risk for poor outcomes for every 5 kg/mg 2 increase in body mass index [87].…”

Section: Obesity and Covid-19mentioning

confidence: 99%

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

2021

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Overweight and obesity have become global epidemics, especially during the lockdown due to the COVID-19 pandemic. The potential of medicinal plants as a better and safe option in treating obesity and overweight has gained attention in recent years. Obesity and overweight has become a major public health concern, and its incidence rising at an alarming rate. Obesity is one of the major types of metabolic syndrome, resulting in various types of problems such as hypertension, diabetes, dyslipidemia, and excess fat accumulation. The current searching was done by the keywords in main indexing systems including Scopus, PubMed/MEDLINE, the search engine of Google Scholar, and Institute for Scientific Web of Science. The keywords were traditional medicine, health benefits, pharmaceutical science, pomegranate, punicalin, punicalagin, and ellagitannins. Google Scholar was searched manually for possible missing manuscripts, and there was no language restriction in the search. This review was carried out to highlight the importance of medicinal plants which are common in traditional medicinal sciences of different countries, especially Asia to prevent and treatment of obesity and overweight during the global pandemic and the post-COVID-19 era.

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Excess body weight is an independent risk factor for severe forms of COVID-19

Cited by 29 publications

References 20 publications

COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury

COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury

Association between obesity and hospital mortality in critical COVID-19: a retrospective cohort study

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

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