Excess Early Postnatal Weight Gain Leads to Thicker and Stiffer Arteries in Young Children

Evelein, Annemieke M. V.; Visseren, Frank L.J.; Ent, Cornelis K. van der; Grobbee, Diederick E.; Uiterwaal, Cuno S.P.M.

doi:10.1210/jc.2012-3208

Cited by 40 publications

(35 citation statements)

References 41 publications

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“…The present data indicate that, after spontaneous catch‐up growth towards a normal length and weight, IMT remains augmented in SGA children aged 3–6 years. Previous data have indicated that more weight gain in early infancy leads to a thicker intima‐ media by late childhood and the present data suggest that weight gain in early childhood (age 3–6 years) has comparable effects, perhaps even into young adulthood .…”

Section: Discussionsupporting

confidence: 74%

The sequence of prenatal growth restraint and post‐natal catch‐up growth leads to a thicker intima‐media and more pre‐peritoneal and hepatic fat by age 3–6 years

et al. 2015

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Section: Discussionsupporting

confidence: 74%

The sequence of prenatal growth restraint and post‐natal catch‐up growth leads to a thicker intima‐media and more pre‐peritoneal and hepatic fat by age 3–6 years

et al. 2015

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“…In this context, birthweight was initially considered a marker of developmental exposure that may relate to later cardio‐metabolic risk. More recently, however, emphasis has turned to rapid early‐life weight gain . Indeed, Leunissen et al .…”

Section: Introductionmentioning

confidence: 99%

Antepartum determinants of rapid early‐life weight gain in term infants born to women with and without gestational diabetes

Kramer

Hamilton

et al. 2014

Clinical Endocrinology

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SummaryObjective Rapid weight gain in the first 3 months of life has been associated with an unfavourable cardio-metabolic phenotype in adulthood. However, little is known about the antepartum determinants of this rapid weight gain, which may reflect key developmental exposures that program metabolic pathways. Thus, we sought to characterize the antepartum determinants of rapid weight gain in the first 3 months of life in infants exposed to gestational diabetes mellitus (GDM), a patient population at risk for early cardio-metabolic disease. Design Prospective observational cohort study. Patients Pregnant women with (n = 90) and without GDM (n = 250) underwent detailed antepartum metabolic characterization, followed by assessment of their term offspring at age 3 months. Measurements Rapid infant weight gain in the first 3 months was defined as weight gain ≥ 0Á5 SD. Results No features of maternal metabolic function in pregnancy (including insulin sensitivity, lipid profile, adiponectin, leptin and C-reactive protein) were associated with infant weight gain in either the GDM or non-GDM group. Interestingly, although all infants were born at term (≥37 weeks), length of gestation was inversely associated with weight gain at 3 months in the infants of women with GDM (b = À148Á5, P = 0Á01). In these infants, length of gestation <39 weeks was an independent predictor of rapid weight gain (OR = 7Á9, 95%CI 1Á7-38, P = 0Á009) in the fully adjusted model. These associations were not observed in infants of women without GDM. Conclusions Delivery before 39 weeks is independently associated with rapid weight gain in the first 3 months of life in term infants of women with GDM and hence may be an antepartum marker of future cardio-metabolic risk.

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“…Current research supports consistent associations of maternal weight gain during gestation, large for gestational age birth size, and rapid weight gain during infancy with BMI, adiposity, or risk of overweight/obesity in childhood through adulthood [4–6]. Consequences of rapid weight gain in infancy are also linked to adverse cardiovascular and metabolic outcomes later in life [7–10]. At present, efforts to prevent and treat obesity during childhood have mixed success [11, 12].…”

Section: Introductionmentioning

confidence: 86%

Design of a Digital-Based, Multicomponent Nutrition Guidance System for Prevention of Early Childhood Obesity

Uesugi¹,

Dattilo²,

Black

et al. 2016

Journal of Obesity

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Interventions targeting parenting focused modifiable factors to prevent obesity and promote healthy growth in the first 1000 days of life are needed. Scale-up of interventions to global populations is necessary to reverse trends in weight status among infants and toddlers, and large scale dissemination will require understanding of effective strategies. Utilizing nutrition education theories, this paper describes the design of a digital-based nutrition guidance system targeted to first-time mothers to prevent obesity during the first two years. The multicomponent system consists of scientifically substantiated content, tools, and telephone-based professional support delivered in an anticipatory and sequential manner via the internet, email, and text messages, focusing on educational modules addressing the modifiable factors associated with childhood obesity. Digital delivery formats leverage consumer media trends and provide the opportunity for scale-up, unavailable to previous interventions reliant on resource heavy clinic and home-based counseling. Designed initially for use in the United States, this system's core features are applicable to all contexts and constitute an approach fostering healthy growth, not just obesity prevention. The multicomponent features, combined with a global concern for optimal growth and positive trends in mobile internet use, represent this system's future potential to affect change in nutrition practice in developing countries.

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Excess Early Postnatal Weight Gain Leads to Thicker and Stiffer Arteries in Young Children

Cited by 40 publications

References 41 publications

The sequence of prenatal growth restraint and post‐natal catch‐up growth leads to a thicker intima‐media and more pre‐peritoneal and hepatic fat by age 3–6 years

The sequence of prenatal growth restraint and post‐natal catch‐up growth leads to a thicker intima‐media and more pre‐peritoneal and hepatic fat by age 3–6 years

Antepartum determinants of rapid early‐life weight gain in term infants born to women with and without gestational diabetes

Design of a Digital-Based, Multicomponent Nutrition Guidance System for Prevention of Early Childhood Obesity

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