2019
DOI: 10.1172/jci.insight.125762
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Excess growth hormone suppresses DNA damage repair in epithelial cells

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Cited by 35 publications
(41 citation statements)
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“…The studies which used a post-irradiation GH treatment to effect recovery of non-tumor cells, did not include a long-term follow up on any subsequent neoplasmic occurrences in the same patients. This could be pivotal based on the above-mentioned recent reports by Chesnokova et al [97] , where a GH excess although anti-apoptotic, actually inhibits DDR, thereby allowing oncogenic transformation in epithelial cells [97] .…”
Section: Resistance To Radiation Therapymentioning
confidence: 99%
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“…The studies which used a post-irradiation GH treatment to effect recovery of non-tumor cells, did not include a long-term follow up on any subsequent neoplasmic occurrences in the same patients. This could be pivotal based on the above-mentioned recent reports by Chesnokova et al [97] , where a GH excess although anti-apoptotic, actually inhibits DDR, thereby allowing oncogenic transformation in epithelial cells [97] .…”
Section: Resistance To Radiation Therapymentioning
confidence: 99%
“…As early as 2004, GH overexpressing EL4 T-cell lymphomas were reported to have reduced apoptosis when treated with methyl methanosulfonate (MMS) and reduced levels of Bax, BAD, and caspases-3, 8, and 9 [95] . A series of reports, especially from Melmed and colleagues, described a GH-induced feedback inhibition on p53 following DNA-damage in cells [96][97][98] . They showed that Nutlin-induced DNA damage and induction of the p53/p21 senescent pathway lead to GH expression in vitro in rodent primary pituitary cultures, in human pituitary adenoma samples and in vivo in C57BL/6 mice [98] .…”
Section: Deregulated Apoptosismentioning
confidence: 99%
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