Excess Health Care Costs Among Elderly Breast Cancer Patients, by Receipt of Human Epidermal Growth Factor Receptor 2-Targeted Therapy: An Analysis of Seer-Medicare Data

Abstract

A77with prevention of chronic disease and cancer over a one-year time horizon in the US. Age-and sex-specific population statistics, incidence, and mortality rates were used to model the prevalence and costs of chronic disease (Alzheimer's, depression/suicide, diabetes, heart failure, Parkinson's, stroke) and cancer (bladder, breast, colorectal, endometrial, esophageal, leukemia, liver, oral, pancreatic, prostate). Relative risks of chronic diseases and cancers by cups of coffee consumed daily were obtained from meta-analyses of prospective cohort and case-control studies. US daily coffee consumption, duration of disease, and attributable disease costs were obtained from the literature. The model was validated by comparing predicted disease-specific health care costs to estimates from published disease burden analyses. Probabilistic sensitivity analysis (PSA) was conducted. Results: The model estimates that US coffee consumption prevents over 50,000 chronic disease and cancer deaths per year and results in an estimated health care savings of $33.4 billion per year