Excess mortality of mental disorder

Harris, E Clare; Barraclough, B. M.

doi:10.1192/bjp.173.1.11

Cited by 1,666 publications

(1,128 citation statements)

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“…Previous research suggests that 30 to 90 percent of those who complete suicide suffered from a depressive disorder (Goldsmith et al, 2002;Lönnqvist, 2000), and that the suicide rate among those with depression may be up to 21 times the population rate (Harris & Barraclough, 1998). At the same time, previous clinical trials have established the effectiveness of SSRIs in reducing depression (Ryan, 2003;Green, 2003;Vaswani & Ramesh, 2003).…”

Section: Introductionmentioning

confidence: 98%

Anti-depressants, suicide, and drug regulation

Ludwig

Marcotte

2005

J. Pol. Anal. Manage.

131

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Section: Introductionmentioning

confidence: 98%

Anti-depressants, suicide, and drug regulation

Ludwig

Marcotte

2005

J. Pol. Anal. Manage.

131

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“…[2][3][4] In particular, serious and persistent mental illnesses (i.e., SMI, including schizophrenia, bipolar disorder, and other nonorganic psychotic disorders) and unipolar depression are leading causes of disability in the US. 2,5 Much of the disability in patients with mental disorders is attributed to co-occurring general medical conditions.…”

Section: Introductionmentioning

confidence: 99%

Quality of Care for Cardiovascular Disease-related Conditions in Patients with and without Mental Disorders

et al. 2008

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OBJECTIVE:We compared the quality of care for cardiovascular disease (CVD)-related risk factors for patients diagnosed with and without mental disorders. METHODS:We identified all patients included in the fiscal year 2005 (FY05) VA External Peer Review Program's (EPRP) national random sample of chart reviews for assessing quality of care for CVD-related conditions. Using the VA's National Psychosis Registry and the National Registry for Depression, we assessed whether patients had received diagnoses of serious mental illness (schizophrenia, bipolar disorder, or other psychoses) or depression during FY05. Using multivariable logistic regression and generalized estimating equation analyses, we assessed patient and facility factors associated with receipt of guideline concordant care for hypertension (total N=24,016), hyperlipidemia (N=46,430), and diabetes (N=10,943).RESULTS: Overall, 70% had good blood pressure control, 90% received a cholesterol (hyperlipidemia) screen, 77% received a retinal exam for diabetes, and 63% received recommended renal tests for diabetes. After adjustment, compared to patients without SMI or depression, patients with SMI were less likely to be assessed for CVD risk factors, notably hyperlipidemia (OR=0.58; p< 0.001), and less likely to receive recommended follow-up assessments for diabetes: foot exam (OR=0.68; p<0.001), retinal exam (OR=0.65; p<0.001), or renal testing (OR= 0.64; p<0.001). Patients with depression were also significantly less likely to receive adequate quality of care compared to non-psychiatric patients, although effects were smaller than those observed for patients with SMI.CONCLUSIONS: Quality of care for major chronic conditions associated with premature CVD-related mortality is suboptimal for VA patients with SMI, especially for procedures requiring care by a specialist.KEY WORDS: quality of care; cardiovascular disease; mental disorders.

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“…23 Together with substance abuse, eating disorders constitute the major contribution to excess mortality from psychiatric disorders. 24 A history of AN is also associated with greater problems with reproduction, 25 osteoporosis, 26,27 continued low BMI, and major depression. 28 The -In women, amenorrhea, and in men, loss of sexual interest and potency (an apparent exception is the persistence of vaginal bleeds in anorexic women who are receiving replacement hormonal therapy, most commonly taken as a contraceptive pill) -There may also be elevated levels of growth hormone, raised levels of cortisol, changes in the peripheral metabolism of the thyroid hormone, and abnormalities of insulin secretion…”

Section: Epidemiologymentioning

confidence: 99%