In this work, the applicability of Free Length and Collision Factor theories to predict multicomponent isentropic compressibilities is analyzed and compared. To this end, appropriate expansions for ternary mixtures were derived from the original works, and then applied to a mixture containing dislike compounds in terms of functional molecular groups. Excess molar volumes from open literature and new experimental ultrasonic velocities of the mixture acetone+methanol+n-hexane were used to compute the corresponding isentropic compressibilities. A good accuracy was obtained when ternary prediction is attempted in this partially soluble mixture at different temperatures by the Collision Factor theory. These results show the versatility of this model for estimation studies in complex multicomponent mixtures enclosing phase splitting.