1990
DOI: 10.1080/07315724.1990.10720408
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Excess vitamin A injures the liver.

Abstract: Chronic vitamin A intoxication in a 56-year-old female is reported. Some abnormal blood chemistries included elevated transaminase and alkaline phosphatase, increased cerebrospinal fluid and portal pressure, and elevated vitamin A in blood and liver. A liver biopsy indicated histologic evidence of perisinusoidal collagen deposition and noncoalescent fat droplets in Ito cells. Caution against the misdiagnosis of alcoholic cirrhosis for vitamin A intoxication is recommended.

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Cited by 9 publications
(3 citation statements)
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“…Nonetheless, highly elevated serum retinol in excess of 3.49 mol/L (100 g/dL) usually is a diagnostic indicator of excess vitamin A intake and hypervitaminosis A (6,8). Some of this abnormal concentration of retinol circulates nonspecifically in association with plasma lipoproteins, as opposed to normal transport bound to retinol binding protein, and thus has a potentially destructive effect on cellular membranes leading to cell and tissue damage (22,36,37). During the course of the present study, no significant changes were noted in the serum retinol concentrations of unsupplemented patients in the trace group, whereas significant increases of Ϸ8% and 18% were observed at years 5 and 12, respectively, among those supplemented with 4500 RE (15 000 IU) vitamin A/d.…”
Section: Discussionmentioning
confidence: 99%
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“…Nonetheless, highly elevated serum retinol in excess of 3.49 mol/L (100 g/dL) usually is a diagnostic indicator of excess vitamin A intake and hypervitaminosis A (6,8). Some of this abnormal concentration of retinol circulates nonspecifically in association with plasma lipoproteins, as opposed to normal transport bound to retinol binding protein, and thus has a potentially destructive effect on cellular membranes leading to cell and tissue damage (22,36,37). During the course of the present study, no significant changes were noted in the serum retinol concentrations of unsupplemented patients in the trace group, whereas significant increases of Ϸ8% and 18% were observed at years 5 and 12, respectively, among those supplemented with 4500 RE (15 000 IU) vitamin A/d.…”
Section: Discussionmentioning
confidence: 99%
“…Vitamin A hepatotoxicity, typically associated with elevated concentrations of liver enzymes such as aspartate transaminase (AST) and alanine transaminase (ALT) (19), has been documented in persons chronically supplemented with doses of vitamin A ≥ 7500 RE (≥ 25 000 IU)/d (20)(21)(22). Only limited evidence is available to suggest that long-term supplementation with vitamin A (≤ 7500 RE/d, or ≤ 25 000 IU/d) may lead to hepatotoxicity in certain individuals (20,23,24).…”
Section: Introductionmentioning
confidence: 99%
“…Serum levels of retinol do not adequately mirror the concentrations of vitamin A in the liver, which is the main site of storage. Toxic levels of vitamin A in the liver are considered to induce liver cirrhosis and portal hypertension (12,13), while in adequate levels, vitamin A seems to prevent liver fibrosis induced by drugs toxic to the liver (14). Vitamin A is stored in the liver in Ito cells, which produce collagen when activated (15).…”
mentioning
confidence: 99%