2021
DOI: 10.1111/iej.13578
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Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

Abstract: Aim To evaluate the effect of excessive caffeine intake on the inflammation/resorption processes associated with periapical periodontitis (PP) in rats. Methodology Sixteen Wistar rats were used. Periapical periodontitis was induced in the four first molars in each animal. The animals were arranged into two groups: control (C)—rats with periapical periodontitis; and caffeine (CAF)—rats with periapical periodontitis under caffeine administration protocol. The CAF animals received 10 mg/100 g of body weight/day o… Show more

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Cited by 16 publications
(9 citation statements)
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“…demonstrated caffeine‐induced apoptosis in osteoblasts via a mitochondria‐dependent pathway [34]. In addition, Several previous studies in rats confirmed that caffeine exacerbated the volume of periapical bone destruction and increased bone loss in ligated teeth [35, 36]. The underlying mechanism of caffeine consumption and periodontitis infection warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…demonstrated caffeine‐induced apoptosis in osteoblasts via a mitochondria‐dependent pathway [34]. In addition, Several previous studies in rats confirmed that caffeine exacerbated the volume of periapical bone destruction and increased bone loss in ligated teeth [35, 36]. The underlying mechanism of caffeine consumption and periodontitis infection warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Kamagata-Kiyoura, Y et al reported that the possible implication of routine caffeine intake in the acceleration of pathological conditions of periodontitis [36]. A study in rats that evaluated the function of caffeine suggested that Caffeine increased bone loss in ligated teeth [37]. Dal-Fabbro et al reported that excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats, and the in ammatory pattern deriving from periapical periodontitis alters the expression of RANKL, IL-1β, and TRAP [38].…”
Section: Discussionmentioning
confidence: 99%
“…The study was conducted in accordance with ethical guidelines approved by the Animal Experiments Local Ethics Committee at Near East University (Protocol No: 2019/02/59), and it was single‐centre, randomized, controlled, single‐blind (with respect to the analyst, who was blinded to the treatments allocated to the rats). The animal sample size was based on previous similar studies that used the same methodology to evaluate bone resorption and biochemical parameters (Dal‐Fabbro et al., 2019, 2021). Besides, G‐power 3.1.9.2 program was performed to ensure the sufficiency of the sample size.…”
Section: Methodsmentioning
confidence: 99%