Excessive Daytime Sleepiness in Multiple System Atrophy (SLEEMSA Study)

Moreno-Lopez, Claudia L; Santamaría, Joan; Salamero, Manuel; Sorbo, Francesca Del; Albanese, Alberto; Pellecchia, Maria Teresa; Barone, Paolo; Overeem, Sebastiaan; Bloem, Bastiaan R.; Aarden, Willemijn C. C. A.; Canesi, Margherita; Antonini, Angelo; Duerr, Susanne; Wenning, Gregor K.; Poewe, Werner; Rubino, Alfonso; Meco, Giuseppe; Schneider, Susanne A.; Bhatia, Kailash P.; Djaldetti, Ruth; Coelho, Miguel; Sampaio, Cristina; Cochen, Valérie; Hellriegel, Helge; Deuschl, Günther; Colosimo, Carlo; Marsili, Luca; Gasser, Thomas; Tolosa, Eduardo

doi:10.1001/archneurol.2010.359

Cited by 87 publications

(45 citation statements)

References 27 publications

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“…Sleep fragmentation was reported by 53% of patients as the most frequent complaint followed by early waking (33%) and insomnia (20%) with no significant difference in PD patients. Excessive daytime sleeping has also been reported according to Ghorayeb et al [41] in half of the MSA patients, while Moreno-Lopez et al [42] has recently reported it in 28% of patients with MSA, weakly correlated with disease severity and not correlated with the amount of dopaminergic treatment. …”

Section: Review On Sleep Disturbances In Msamentioning

confidence: 77%

Cognitive and Sleep Features of Multiple System Atrophy: Review and Prospective Study

et al. 2014

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Background: The profile and degree of cognitive impairment in Multiple System Atrophy (MSA) and the impact of sleep disorders, REM sleep behavior disorder (RBD) in particular, in parkinsonism-related cognitive deficits are currently being debated. Summary: We reviewed the cognitive, affective and sleep findings in MSA and also carried out a longitudinal investigation of 10 MSA patients. At the first evaluation, 3 patients showed isolated cognitive deficits. After a mean of 16 months, these patients remained unchanged, while 1 patient worsened from a normal condition. No significant differences emerged when the cognitive, affective and video-polysomnographic findings of MSA-P and MSA-C were compared. Depression was present in half of the patients, although it did not influence their cognitive performance. Comparisons between the first and second evaluation data showed significant worsening in visual attention and in ADL/IADL and UMSARS. Key Messages: Isolated cognitive deficits are evidenced in a minority of MSA patients with the absence of a clear-cut diagnosis of dementia in the early stages of the disease. Attention and executive functions are often impaired. This study with a short follow-up period showed that RBD, although present in almost all patients affected by MSA, does not appear a clear early marker of cognitive impairment. Future longer-term studies with a larger patient sample are thus encouraged.

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Section: Review On Sleep Disturbances In Msamentioning

confidence: 77%

Cognitive and Sleep Features of Multiple System Atrophy: Review and Prospective Study

et al. 2014

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“…In another study, 55% of PD and PSP patients had OSA, which increased with age in both groups, but PSP patients had worse sleep efficiency[163]. A questionnaire study comparing MSA, PD, and control subjects found sleep-related breathing complaints in 30% PD, 19.8% control, and 54.7% MSA subjects[272]. Among MSA, PSP, and PD patients, 38.5%, 14.3%, and 18.8%, respectively, screened high risk for sleep apnea[273].…”

Section: Sleep Related Breathing Disordersmentioning

confidence: 99%

“…Excessive daytime somnolence is common among patients with Parkinson’s disease, affecting 20-60% of patients[57,89,102,123,124,137,144,145,151,182,183,243,259,261,270,272,273,280-296]. Multiple factors influence the prevalence of EDS, including duration and severity of disease, age, gender, cognition, presence of nocturnal sleep disorders, and mood disorders.…”

Section: Excessive Daytime Sleepinessmentioning

confidence: 99%

“…One study found no difference in EDS between essential tremor (ET) and PD subjects[286], while another found EDS to be more common in PD than ET[280]. In a study comparing daytime sleepiness in MSA, PD, and controls, EDS was found in 28%, 29%, and 2% respectively[272]. EDS appears to be more common among subjects with Parkinson’s disease dementia (PDD) or DLB compared to PD patients without dementia[182,281].…”

Section: Excessive Daytime Sleepinessmentioning

confidence: 99%

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A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

274

249

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Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

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“…For example, studies have found that more PD patients with RBD have subjective sleepiness compared to those without RBD [22,23]. Verbaan et al [24] showed that RLS severity correlated with sleepiness, while Moreno-Lopez et al [25] found that RLS was an independent predictor of EDS in PD patients. However, the scores of PDSS-2 item 4-5 that are meant to screen for RLS/PLMS, and item 15 to screen for OSA provided by our study do not support a contributory role for those sleep disorders on daytime sleepiness as EDS, SA or EDS + SA.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Association between Sleep Disturbances and Daytime Somnolence in Parkinson’s Disease

2018

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Background: Sleep disturbance is a common problem among patients with Parkinson’s disease (PD). Objectives: To investigate the prevalence of daytime somnolence and night-time sleep disturbances; to characterise the night-time sleep disturbance in patients with daytime somnolence; and to determine the correlation between daytime somnolence and night-time sleep disturbances. Methods: One hundred and sixty patients with PD were included in the study. Each patient completed the Thai version of the Epworth Sleepiness Scale (ESS) questionnaire to evaluate excessive daytime sleepiness (EDS), and the PD Sleep Scale version-2 (PDSS-2) questionnaire to evaluate night-time sleep disturbance. Subjective sleep information and details about the presence or absence of sleep attack (SA) were also obtained from the patients. Results: The types of daytime somnolence found in this study were EDS, SA, and combination of EDS and SA (EDS + SA) with the prevalence rates of 22.5, 3.1 and 6.3%, respectively. The prevalence of night-time sleep disturbance was 46.9%. The most common nocturnal disturbance (82.5%) was “get up at night to pass urine”. There was a significant positive correlation between the ESS score and PDSS-2 total score with a correlation coefficient of 0.16 (p = 0.043). Patients with “EDS + SA” were the most affected by nocturnal disturbances, as they represented the largest group among those patients with night-time disturbances and had the highest PDSS-2 total score (p < 0.05). Conclusion: There are differences in nocturnal sleep disturbances among PD patients with different types of daytime somnolence. The significant positive correlation between the ESS and the PDSS-2 total scores suggests that night-time sleep disturbance may influence daytime somnolence.

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Excessive Daytime Sleepiness in Multiple System Atrophy (SLEEMSA Study)

Cited by 87 publications

References 27 publications

Cognitive and Sleep Features of Multiple System Atrophy: Review and Prospective Study

Cognitive and Sleep Features of Multiple System Atrophy: Review and Prospective Study

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Association between Sleep Disturbances and Daytime Somnolence in Parkinson’s Disease

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