Excessive gestational weight gain in the first trimester is associated with risk of gestational diabetes mellitus: a prospective study from Southwest China

Lan, Xi; Zhang, Yi‐Qi; Dong, Hongli; Zhang, Ju; Zhou, Fengming; Bao, Yanju; Zhao, Rongzhen; Cai, Congjie; Bai, Dan; Pang, Xinxin; Zeng, Guo

doi:10.1017/s1368980019003513

Cited by 25 publications

(23 citation statements)

References 33 publications

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“…Conversely, women who didn't diagnosed with gestational diabetes mellitus may be less likely to follow a diet or exercise, which could lead to more weight gain. This result was similar to the ndings of domestic and foreign academics [15,16] .In addition, it has been reported [17] that excessive weight gain in rst trimester was relative to an increased risk of gestational diabetes mellitus, regardless of pre-pregnancy weight. We did not make a consideration of weight gain in rst trimester, thus it may lead to an inconsistency between our ndings and those of some studies [18] .This also suggested that we should not neglect weight management in rst trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 89%

Examining the Effection of Second-and Third-trimester Rate of Gestational Weight Gain on Perinatal Outcomes Among Chinese Twin Gestations Based on the Provisional Guidelines: A Retrospective Cohort Study

Lin¹,

Weng²,

Lin³

et al. 2020

Preprint

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Background: This paper investigated how second and third trimester gestational weight gain relates toperinatal outcomes among normal weight women with twin pregnancies in Fujian, China. Methods: A retrospective study on the medical records of 931 normal weight twin pregant women was conducted in Fujian Maternity and Child Health Hospital from 2014 to 2018.The 2nd and 3rd trimester weekly weight gain rate were calculated and categorized women as gaining below, within, or above the 2009 Institute of Medicine (IOM) recommended rates . The association between trimester-specific weight gain rate and perinatal outcome was performed by traditional regression analysis among groups.Results:A total of 931 pregnant women and 1862 neonates were included for analysis. 25.9% ,19.8% and 54.3%% of women had less than, greater than and within the recommended rates of gain in the 2nd and 3rd trimester, respectively. Multivariate Logistic regression analysis showed that greater than recommended rates of weight gain in 2nd trimester decreased the risks of preeclampsia (adjusted OR:0.458,95% CI:0.255~0.824). Less than recommended rates of weight gain in 3rd trimester increased the risk of premature delivery（adjusted OR=1.926,95%CI:1.403~2.644）, gestational diabetes mellitus (adjusted OR = 2.052,95%CI:1.417~2.972), intrahepatic cholestasis syndrome (adjusted OR = 3.016,95%CI:1.057~8.606), premature rupture of the membrane (adjusted OR = 1.722,95%CI:1.180~2.512) and neonatal respiratory distress syndrome (adjusted OR = 5.135,95%CI:1.701~15.498) and decreased the risk of cesarean section (adjusted OR = 0.587,95%CI:0.385~0.893) .In addition, greater than recommended rates of weight gain in 3rd trimester was associated with increased risks in premature delivery (adjusted OR=1.818,95%CI:1.307~2.527), and gestational hypertension (adjusted OR=2.098,95%CI:1.018~4.324) as well as preeclampsia(adjusted OR:2.029, 95%CI:1.331~3.093). The stratified analysis of weight gain in 3rd trimester showed that there was no significant difference in the incidence of adverse pregnancy outcomes compared to weight gain rate groups in 2nd trimester.Conclusions: While this study showed gestational weight gain rate less than or greater than in 3rd trimester were associated with some adverse maternal and neonatal outcomes, further studies of prospective and multi-center researches are required to explore alternate ranges of gestational weight gain rate in twin pregnancies.

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Section: Discussionsupporting

confidence: 89%

Examining the Effection of Second-and Third-trimester Rate of Gestational Weight Gain on Perinatal Outcomes Among Chinese Twin Gestations Based on the Provisional Guidelines: A Retrospective Cohort Study

Lin¹,

Weng²,

Lin³

et al. 2020

Preprint

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“…Compared with lower rate of gestational weight gain (less than 0.28 kg per week), a rate of weight gain of 0.28 kg per week or more was associated with an increased risk of GDM (OR = 2.03, 95% CI: 1.15-3.59) according to a study conducted in Peking University First Hospital in China [38]. Another prospective study from Southwest China showed that gestational weight gain in the first trimester above IOM recommendations increased the risk of GDM among underweight (OR = 2.50, 95% CI: 1.11-5.66), normal-weight (OR = 1.40, 95% CI: 1.02-1.91), and overweight/obese women (OR = 3.02, 95% CI: 1.12-8.14) compared with those within IOM recommendations, which indicated that excessive gestational weight gain in the first trimester is associated with increased risk of GDM regardless of pre-pregnancy BMI [51].…”

Section: Excessive Gestational Weight Gainmentioning

confidence: 94%

Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China

Juan

Yang

2020

IJERPH

207

128

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Gestational diabetes mellitus (GDM) has become an epidemic and has caused a tremendous healthy and economic burden in China, especially after the “two-child policy” put into effect on October 2015. The prevalence of GDM has continued to increase during the past few decades and is likely to see a further rise in the future. The public health impact of GDM is becoming more apparent in China and it might lead to the development of chronic non-communicable diseases in the long-term for both mothers and their children. Early identification of high-risk individuals could help to take preventive and intervention measures to reduce the risk of GDM and adverse perinatal outcomes. Therefore, a focus on prevention and intervention of GDM in China is of great importance. Lifestyle interventions, including dietary and physical exercise intervention, are effective and first-line preventive strategies for GDM prevention and intervention. The GDM One-day Care Clinic established in 2011, which educates GDM patients on the basic knowledge of GDM, dietary intervention, physical exercise, weight management, and blood glucose self-monitoring methods, sets a good model for group management of GDM and has been implemented throughout the hospitals as well as maternal and child health centers in China. The current review focus on the prevalence, risk factors, as well as prevention and lifestyle intervention of GDM in China for better understanding of the latest epidemiology of GDM in China and help to improve maternal and neonatal pregnancy outcomes and promote long-term health for women with GDM.

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“…This result is 1•3 times higher than in a population of pregnant women without SARS-CoV-2 in Japan, where 2•7% were diagnosed with gestational diabetes [33]. Prior literature has established a relationship between elevated BMI and gestational weight gain on the presence of gestational diabetes; however, lack of reporting on BMI in women with gestational diabetes in this review inhibits us from inferring the same in SARS-CoV-2 positive pregnant women [34,35].…”

Section: Discussionmentioning

confidence: 59%

Impact of coronavirus disease 2019 on the clinical outcomes and placental pathology of pregnant women and their infants: A Systematic Review

Oltean¹,

Tran²,

Lawrence³

et al. 2020

Preprint

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Pregnant women are susceptible to viral infections due to physiological changes such as cell-mediated immunity. No severe adverse pregnancy or neonatal outcomes have been consistently reported in COVID-19 positive pregnancy cases. There are controversies around the role of COVID-19 in pregnancy. A systematic review was conducted to examine clinical maternal and neonatal clinical outcomes. Studies were included if they reported COVID-19 infection among pregnant women and/or COVID-19 positive neonates as validated by positive antibody testing or viral testing using Polymerase Chain Reaction. Case series, case reports, case-control studies, and comparative studies were included. 837 records were identified, resulting in 525 records for level I screening. 41 were included after full-text review. Results suggest elevated rates of ICU admission, gestational diabetes, preeclampsia, C-sections, pre-term birth, and CRP in comparison to pregnant women without SARS-CoV-2. Careful monitoring of pregnancies with SARS-CoV-2 to minimize adverse clinical outcomes is recommended.

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Excessive gestational weight gain in the first trimester is associated with risk of gestational diabetes mellitus: a prospective study from Southwest China

Cited by 25 publications

References 33 publications

Examining the Effection of Second-and Third-trimester Rate of Gestational Weight Gain on Perinatal Outcomes Among Chinese Twin Gestations Based on the Provisional Guidelines: A Retrospective Cohort Study

Examining the Effection of Second-and Third-trimester Rate of Gestational Weight Gain on Perinatal Outcomes Among Chinese Twin Gestations Based on the Provisional Guidelines: A Retrospective Cohort Study

Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China

Impact of coronavirus disease 2019 on the clinical outcomes and placental pathology of pregnant women and their infants: A Systematic Review

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