Excessive Intake of Zinc Impairs Immune Responses

Chandra, R. K.

doi:10.1097/00006454-198501000-00044

Cited by 31 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, other studies on neonates have demonstrated the adverse effects of zinc excess (Shankar & Prasad, 1998). In humans, Chandra (1984) has reported a substantial impairment of lymphocyte proliferative responses and a reduction in chemotaxis and phagocytosis of circulating polymorphonuclear leukocytes in healthy adults who received a 10 -20-fold excess of the daily recommended zinc requirement. Other studies suggest that very high intakes by children and adults can induce anaemia, growth retardation, copper deficiency and immunosuppression.…”

Section: Effect Of Excessive Zinc Intakementioning

confidence: 99%

Zinc and immune function

2002

View full text Add to dashboard Cite

It is well recognized that zinc is an essential trace element, influencing growth and affecting the development and integrity of the immune system. Research has begun to clarify the molecular mechanisms underlying the action of zinc on the immune function. It is clear that this trace element has a broad impact on key immunity mediators, such as enzymes, thymic peptides and cytokines, explaining the paramount importance of zinc's status on the regulation of lymphoid cell activation, proliferation and apoptosis. Ongoing and future studies regarding the immunological status of zinc deficiency 'at risk' groups could lead to public health interventions with nutritional doses of zinc supplements to prevent alteration of the immune system and improve resistance to infections.

show abstract

Section: Effect Of Excessive Zinc Intakementioning

confidence: 99%

Zinc and immune function

2002

View full text Add to dashboard Cite

show abstract

“…The study demonstrated that low dose supplementa tion of twice the RDA for vitamin C (120 mg/day) and 60 -75% of the RDA for men and women, respectively, for zinc (20 mg/day) was sufficient to correct deficiencies of these nutrients. Previous studies have demonstrated that the use of large doses of micronutrient supplementation may have adverse effects on health outcomes in older adults, as demon strated for zinc by Chandra (1984) and Bogden etal. (1990).…”

Section: Discussionmentioning

confidence: 94%