Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice

Sun, Ting; Sakata, Fumiko; Ishii, Takako; Tawada, Mitsuhiro; Suzuki, Yoshio; Kinashi, Hiroshi; Kuriyama, Takayuki; Takei, Yoshiyuki; Maruyama, Shoichi; Mizuno, Masashi; Ito, Yasuhiko

doi:10.1093/ndt/gfz045

Cited by 16 publications

(22 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, in the study by Sahinoz et al, higher plasma inflammatory markers (IL-6 and C-reactive protein) correlated with an increased muscle and skin sodium content [ 24 ]. This correlation heralds an interesting link between interstitial sodium and chronic inflammation, as already reported in experimental studies [ 26 , 27 , 28 ]. Thus, in nephrectomized rats, exposure to two weeks of higher salt intake increased the levels of IL-6, CMP-1, and TNF-alfa in the dialysate.…”

Section: Volume-independent Sodium Toxicity In End-stage Kidney Diseasesupporting

confidence: 71%

“…Finally, they reported that increasing the sodium intake induced an increase in peritoneal permeability (D/P creatinine increase). Each of these observed abnormalities reverted to normal after the sodium intake was reduced [ 26 ]. One notes that the results of this study [ 26 ] were consistent with findings from an early experiment on Winster rats showing that exposure to a higher sodium intake was associated with the thickening of the peritoneal membrane and peritoneal fibrosis as well as causing an epithelial-to-mesenchymal transition [ 27 ].…”

Section: Volume-independent Sodium Toxicity In End-stage Kidney Diseasementioning

confidence: 99%

See 1 more Smart Citation

Volume-Independent Sodium Toxicity in Peritoneal Dialysis: New Insights from Bench to Bed

Borrelli

Nicola

Gregorio

et al. 2021

IJMS

View full text Add to dashboard Cite

Sodium overload is common in end-stage kidney disease (ESKD) and is associated with increased cardiovascular mortality that is traditionally considered a result of extracellular volume expansion. Recently, sodium storage was detected by Na23 magnetic resonance imaging in the interstitial tissue of the skin and other tissues. This amount of sodium is osmotically active, regulated by immune cells and the lymphatic system, escapes renal control, and, more importantly, is associated with salt-sensitive hypertension. In chronic kidney disease, the interstitial sodium storage increases as the glomerular filtration rate declines and is related to cardiovascular damage, regardless of the fluid overload. This sodium accumulation in the interstitial tissues becomes more significant in ESKD, especially in older and African American patients. The possible negative effects of interstitial sodium are still under study, though a higher sodium intake might induce abnormal structural and functional changes in the peritoneal wall. Interestingly, sodium stored in the interstial tissue is not unmodifiable, since it is removable by dialysis. Nevertheless, the sodium removal by peritoneal dialysis (PD) remains challenging, and new PD solutions are desirable. In this narrative review, we carried out an update on the pathophysiological mechanisms of volume-independent sodium toxicity and possible future strategies to improve sodium removal by PD.

show abstract

Section: Volume-independent Sodium Toxicity In End-stage Kidney Diseasesupporting

confidence: 71%

Section: Volume-independent Sodium Toxicity In End-stage Kidney Diseasementioning

confidence: 99%

Volume-Independent Sodium Toxicity in Peritoneal Dialysis: New Insights from Bench to Bed

Borrelli

Nicola

Gregorio

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Just as Li Han [20] believed that the Ccr of patients with low transport were not easy to reach 60L/1.73 m 2 , while its technical survival rate were not low but even exceed that of patients with high transport. A study from Japan [21] also demonstrated the value of high P/D Cr was also associated closely with higher mortality and failure of peritoneal dialysis. Our study compared different gender groups which suggested that the values of P/D Cr of male patients were higher than that of female patients on average, which was consistent with the ndings found by Lin tao [22] that male gender was a risk factor for high peritoneal transport status.…”

Section: Discussionmentioning

confidence: 92%

Correlations between gender, age and the risk of withdrawal from peritoneal dialysis

Zhang¹,

He²,

Wan³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background With the increasing incidence of end stage renal disease(ESRD),peritoneal dialysis(PD) has become the preferred method of kidney replacement therapy for an increasing number of patients with end stage renal disease due to its many advantages.The intent of this study was to explore the correlations between sex, age and risk of withdrawal from peritoneal dialysis.Methods All patients who underwent PD catheterization and initiated PD at Wuhan No.1 Hospital between 2013 and 2018 were screened.Clinical information of these patients was collected and compared according to gender and age,then was applied to the Cox proportional hazards model to determine the impact of factors of withdrawal from peritoneal dialysis.Results ①Hazard ratios(HRs) of withdrawal of PD associate with gender and age at initiation were 0.736(P = 0.289)、1.151༈P = 0.489༉respectively.Nonetheless,male patients under 60 years old had a 1.58-fold higher risk of withdrawal than others(HR 0.63,P = 0.031).②The withdrawal risk of patients with total Creatinine clearance rate (Ccr) above 60L/W was 82.4% higher than that of patients who did not meet the standard (HR 1.82,P = 0.005).③The withdrawal risk of patients with high D/P Creatinine༈Cr༉value which was calculated from peritoneal equilibration test(PET) were 2.06 times higher than low-average and high-average transport patients(HR2.06,P = 0.008).④Patients with serum albumin above 35 g/L were intended to withdraw from PD than those below 35 g/L (HR 0.56,P = 0.006).Conclusions There were significant differences in total KT/V, total Ccr,serum creatinine(Scr) and blood Urea nitrogen(BUN)among patients with PD of different gender and age.The analysis showed that male patients under 60 years old, Ccr, value of D/Pcr and serum albumin had a high correlation with the technical survival rates.While gender or age at PD initiation were not associated with technique survival,male patients under 60 years old had a 1.58-fold higher risk of withdrawal from PD than others.The outcome that the withdrawal risk of patients with Ccr above 60L/W was 82.4% higher than other patients who did not meet the standard suggested that Ccr was not suitable as an index for evaluating the adequacy of PD,especially for men under 60 years old.And patients with high D/Pcr value or with serum albumin under 35 g/L were related risk factors for technique survival.

show abstract

“…This finding is relevant because persistence of volume overload heralds a 60% higher mortality risk [84]. Interestingly, recent experimental findings have reported that high sodium intake is related to direct toxicity on the peritoneal membrane, leading to chronic inflammation, fibrosis, and hypervascularization, increasing, in turn, peritoneal permeability [86].…”

Section: Sodium Intake In End-stage Kidney Diseasementioning

confidence: 97%

Sodium Intake and Chronic Kidney Disease

Borrelli

Provenzano

Gagliardi

et al. 2020

IJMS

View full text Add to dashboard Cite

In Chronic Kidney Disease (CKD) patients, elevated blood pressure (BP) is a frequent finding and is traditionally considered a direct consequence of their sodium sensitivity. Indeed, sodium and fluid retention, causing hypervolemia, leads to the development of hypertension in CKD. On the other hand, in non-dialysis CKD patients, salt restriction reduces BP levels and enhances anti-proteinuric effect of renin–angiotensin–aldosterone system inhibitors in non-dialysis CKD patients. However, studies on the long-term effect of low salt diet (LSD) on cardio-renal prognosis showed controversial findings. The negative results might be the consequence of measurement bias (spot urine and/or single measurement), reverse epidemiology, as well as poor adherence to diet. In end-stage kidney disease (ESKD), dialysis remains the only effective means to remove dietary sodium intake. The mismatch between intake and removal of sodium leads to fluid overload, hypertension and left ventricular hypertrophy, therefore worsening the prognosis of ESKD patients. This imposes the implementation of a LSD in these patients, irrespective of the lack of trials proving the efficacy of this measure in these patients. LSD is, therefore, a rational and basic tool to correct fluid overload and hypertension in all CKD stages. The implementation of LSD should be personalized, similarly to diuretic treatment, keeping into account the volume status and true burden of hypertension evaluated by ambulatory BP monitoring.

show abstract

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice

Cited by 16 publications

References 46 publications

Volume-Independent Sodium Toxicity in Peritoneal Dialysis: New Insights from Bench to Bed

Volume-Independent Sodium Toxicity in Peritoneal Dialysis: New Insights from Bench to Bed

Correlations between gender, age and the risk of withdrawal from peritoneal dialysis

Sodium Intake and Chronic Kidney Disease

Contact Info

Product

Resources

About