2007
DOI: 10.1016/j.expneurol.2007.01.027
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Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease

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Cited by 208 publications
(156 citation statements)
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“…Interestingly, worsening of bradykinesia has recently been reported following 5 Hz (Eusebio et al, 2008), 10 Hz (Timmermann et al, 2004;Eusebio et al, 2008) as well as 20 Hz (Fogelson et al, 2005;Chen et al, 2007;Eusebio et al, 2008) low-frequency stimulation of the STN in Parkinson's disease patients. Clearly, these observations further support the role of increased synchronization over a broad frequency range in Parkinson's disease motor deficits.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, worsening of bradykinesia has recently been reported following 5 Hz (Eusebio et al, 2008), 10 Hz (Timmermann et al, 2004;Eusebio et al, 2008) as well as 20 Hz (Fogelson et al, 2005;Chen et al, 2007;Eusebio et al, 2008) low-frequency stimulation of the STN in Parkinson's disease patients. Clearly, these observations further support the role of increased synchronization over a broad frequency range in Parkinson's disease motor deficits.…”
Section: Discussionmentioning
confidence: 99%
“…Abnormal synchronization of oscillatory LFP activity over 13-30 Hz has been recorded from basal ganglia nuclei in the 6-hydroxydopamine-lesioned rodent model of PD (Sharott et al, 2005) and PD patients withdrawn from their usual medication (Levy et al, 2002;Priori et al, 2004;Doyle et al, 2005). Furthermore, the degree of suppression of ␤ activity by levodopa correlates with the levodopa-induced improvement in motor symptoms (Kü hn et al, 2006), the latency of ␤ suppression during movement correlates with reaction time in PD (Kühn et al, 2004;Williams et al, 2005), and stimulation at ␤ frequency may lead to moderate slowing of movement in patients with relatively preserved motor performance at the time (Chen et al, 2007). Here, we provide further correlative evidence for a link between ␤ activity and bradykinesia in PD patients.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the cutoff frequency may change with the stimulation burst parameters [e.g., burst duration and frequency and number of the pulses/burst (McIntyre and Grill, 2002)]. Recent studies indicate a relationship between ␤-band oscillations and akinesia (Chen et al, 2007). Because the GP oscillatory bursts Low-pass filtering was also found between MI and the periphery level, in which MI stimulations of 10 Hz and higher did not evoke movement.…”
Section: Low-pass Filter Properties Of the Bg-cortical-muscle Networkmentioning
confidence: 99%