Transport properties of highly mobile 2D electrons in symmetric GaAs quantum wells with two populated subbands placed in titled magnetic fields are studied at high temperatures. Quantum positive magnetoresistance (QPMR) and magneto-intersubbands resistance oscillations (MISO) are observed in quantizing magnetic fields, B ⊥ , applied perpendicular to the 2D layer. QPMR displays contributions from electrons with considerably different quantum lifetimes, τ (1,2) q , confirming the presence of two subbands in the studied system. MISO evolution with B ⊥ agrees with the obtained quantum scattering times only if an additional reduction of the MISO magnitude is applied at small magnetic fields. This indicates the presence of a yet unknown mechanism leading to MISO damping. Application of in-plane magnetic field produces a strong decrease of both QPMR and MISO magnitude. The reduction of QPMR is explained by spin splitting of Landau levels indicating g-factor, g ≈0.4, which is considerably less than the g-factor found in GaAs quantum well with a single subband populated. In contrast to QPMR the decrease of MISO magnitude is largely related to the in-plane magnetic field induced entanglement between quantum levels in different subbands that, in addition, increases the MISO period.