2020
DOI: 10.1371/journal.pone.0237946
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Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance

Abstract: Dietary fat is discussed to be critical in the development of non-alcoholic fatty liver disease. Here, we assess the effect of exchanging dietary fat source from butterfat to extra virgin olive oil on the progression of an already existing diet-induced non-alcoholic fatty liver disease in mice. Female C57BL/6J mice were fed a liquid butterfat-, fructose-and cholesterolrich diet (BFC, 25E% from butterfat) or control diet (C, 12%E from soybean oil) for 13 weeks. In week 9, fat sources of some BFC-and C-fed mice … Show more

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Cited by 6 publications
(7 citation statements)
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“…Further, analysing individual parameters of parenchymal damage, we observed more pronounced fatty accumulation in the liver of rats of the TAA+O group in respect to the TAA group. It should be noted that our results are in accordance with the literature data showing the detrimental hepatic effect of VOO [45]. For example, Kouka et al, showed that VOO, especially when rich in polyphenolic content, induced oxidative stress in a rat's liver [46].…”
Section: Groupssupporting
confidence: 93%
“…Further, analysing individual parameters of parenchymal damage, we observed more pronounced fatty accumulation in the liver of rats of the TAA+O group in respect to the TAA group. It should be noted that our results are in accordance with the literature data showing the detrimental hepatic effect of VOO [45]. For example, Kouka et al, showed that VOO, especially when rich in polyphenolic content, induced oxidative stress in a rat's liver [46].…”
Section: Groupssupporting
confidence: 93%
“…In humans, levels of sitosterols in the liver in adults with NAFLD have shown an inverse correlation with the degree of steatosis and lobular inflammation by liver biopsy [ 311 ] In animal models, liver damage induced by a high-fat diet was significantly reduced by supplementation with EVOO [ 312 , 313 ], EPA + DHA [ 314 , 315 , 316 ], DHA + EVOO [ 317 ] EPA + hydroxytyrosol [ 318 , 319 , 320 , 321 ], or hydroxytyrosol [ 322 ], showing beneficial effects on inflammation, lipid content, and hepatocyte gene expression. This evidence is mixed, as other animal models have not demonstrated a positive effect of EVOO and its phenolic compounds on the development of NAFLD [ 189 ] or its regression [ 323 ]. The beneficial effect of EVOO against NAFLD could be explained by mitochondrial protection—preventing the decrease in nitrated fatty-acid levels caused by a high-fat diet [ 324 ]—this ability being directly related to its phenolic content [ 325 ].…”
Section: Resultsmentioning
confidence: 99%
“…[36] which indicated that excessive OO intake weaken its hypoglycemic effect. [37] Furthermore, Youzan et al [38] reported that a high dietary intake of OO impaired lipid metabolism and liver function. High-fat diets containing SO have been shown to increase the concentration of circulating INS compared to SO-containing normal-fat diets, which may be because SO adversely affects insulin sensitivity.…”
Section: Discussionmentioning
confidence: 99%