Excipients for Oral Liquid Formulations

Anderson, Meagan; Opawale, Foyeke O.; Rao, Mukund Palat; Delmarre, David; Anyarambhatla, Gopal

doi:10.1201/9781420004137.ch11

Cited by 2 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These particular solvents are often used to extract lipid components from mixtures ( Ramesh et al, 1979 ; Goldsmith et al, 1988 ; Mao-Qiang et al, 1996 ; Cabrini et al, 1992 ; Crabbe et al, 2001 ; Lin et al, 2004 ). The fact that sucralose is readily soluble in alcohols was corroborated by others ( Bennett et al, 1992 ; Anderson et al, 2006 ; Li et al, 2010 ).…”

Section: Potential Toxicity From Habitual Sucralose Ingestionsupporting

confidence: 61%

“…The decrease in the concentration of a xenobiotic compound as it passes through the GIT and liver is termed the “first-pass effect” ( Riegelman and Rowland, 1973 ; Iwamoto and Klaassen, 1977 ; Shimomura et al, 2002 ; Watkins, 1997 ; Paine and Thummel, 2003 ; Paine, 2009 ). The intestinal component of the first-pass effect is especially significant in the disposition of sucralose because the majority of this OC sweetener is reportedly unabsorbed from the small intestine after ingestion ( Grice and Goldmith, 2000 ) even though it is an amphiphilic compound with appreciable lipid solubility ( Hough and Khan, 1978 ; 1989 ; Anderson et al, 2006 ; Li et al, 2010 ). Further, higher doses of orally administered sucralose in humans are associated with lower urinary excretion that suggests sucralose absorption is reduced at increased concentrations ( Roberts et al, 2000 ).…”

Section: Effects Of Sucralose On Presystemic Detoxification Mechanismmentioning

confidence: 99%

“…The range of product utilization is more extensive for sucralose than for other artificial sweeteners due to its physicochemical properties. For example, sucralose is readily soluble in ethanol, methanol, and water ( Bennett et al, 1992 ; Anderson et al, 2006 ; Merck Index, 2006; Li et al, 2010 ), and this solubility profile contributes to its versatility in both fat- and water-based food and beverage applications including alcoholic drinks. Other common artificial sweeteners such as aspartame, sodium saccharin, and acesulfame-potassium (ace-K) are only slightly or sparingly soluble in ethanol and / or methanol ( Schiffman and Gatlin, 1993 ; Merck Index, 2006) and have more limited product applications.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Schiffman

Rother

2013

Journal of Toxicology and Environmental Health, Part B

137

107

View full text Add to dashboard Cite

Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a role in sweet taste sensation and hormone secretion. In rats, sucralose ingestion was shown to increase the expression of the efflux transporter P-glycoprotein (P-gp) and two cytochrome P-450 (CYP) isozymes in the intestine. P-gp and CYP are key components of the presystemic detoxification system involved in first-pass drug metabolism. The effect of sucralose on first-pass drug metabolism in humans, however, has not yet been determined. In rats, sucralose alters the microbial composition in the gastrointestinal tract (GIT), with relatively greater reduction in beneficial bacteria. Although early studies asserted that sucralose passes through the GIT unchanged, subsequent analysis suggested that some of the ingested sweetener is metabolized in the GIT, as indicated by multiple peaks found in thin-layer radiochromatographic profiles of methanolic fecal extracts after oral sucralose administration. The identity and safety profile of these putative sucralose metabolites are not known at this time. Sucralose and one of its hydrolysis products were found to be mutagenic at elevated concentrations in several testing methods. Cooking with sucralose at high temperatures was reported to generate chloropropanols, a potentially toxic class of compounds. Both human and rodent studies demonstrated that sucralose may alter glucose, insulin, and glucagon-like peptide 1 (GLP-1) levels. Taken together, these findings indicate that sucralose is not a biologically inert compound.

show abstract