Excision of Oral Leukoplakia by CO2 Lasers Versus Traditional Scalpel: A Comparative Study

Tambuwala, Aruna; Sangle, Amit; Khan, Akram; Sayed, Aatif

doi:10.1007/s12663-013-0519-2

Cited by 39 publications

(24 citation statements)

References 12 publications

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“…In contrast, the CO2 laser by sealing blood vessels, lymphatics, and nerve endings, reduces to a minimum the local inflammatory response, which is related to lower levels of glucocorticoids, epinephrine and norepinephrine, and therefore to lower pain level. [5,8,9,21,22,27] Considering that skin is one of the tissues where the nociceptive system is most figurative, it is to be expected that the CO2 laser's ability to reduce stimulation of the skin nociceptive system may also be associated with a lower autonomic nervous system stimulation of the remaining tissues and organs to be operated upon, resulting therefore in discrete hemodynamic variations as registered in our study.…”

Section: Comparison Of the Hemodynamic Response In General Anesthesiamentioning

confidence: 57%

Comparison of the Hemodynamic Response in General Anesthesia between Patients Submitted to Skin Incision with Scalpel and CO2 Laser Using Dogs as an Animal Model. A Preliminary Study Miguel Carreira L 1, 2, 3, *, Ramalho R3 , Nielsen

2017

ARC Journal of Anesthesiology

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Section: Comparison Of the Hemodynamic Response In General Anesthesiamentioning

confidence: 57%

Comparison of the Hemodynamic Response in General Anesthesia between Patients Submitted to Skin Incision with Scalpel and CO2 Laser Using Dogs as an Animal Model. A Preliminary Study Miguel Carreira L 1, 2, 3, *, Ramalho R3 , Nielsen

2017

ARC Journal of Anesthesiology

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“…Our study was not designed to evaluate the effect of the nature of the treatment. A comparative study with bilateral leukoplakia (one side of the lesion excised using CO2 laser and the other side using scalpel) has shown that advantages of laser include less bleeding intra operatively, less swelling and scarring post-operatively than scalpel ( 26 ). There was no significant difference in terms of post-operative pain.…”

Section: Discussionmentioning

confidence: 99%

Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment

Cloître¹,

Rosa²,

Arrivé³

et al. 2018

Med Oral

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BackgroundOral cancer is a public health issue worldwide. Oral potentially malignant disorders (OMPDs) are lesions of the oral mucosa that are predisposed to malignant transformation. The mainstay of OMPDs treatment around the world is now the carbon dioxide (CO2) laser but the reported recurrence and malignant transformation rates vary widely in the literature. We aimed to estimate the recurrence and the malignant transformation rates of OPMDs treated with CO2 laser at the University Hospital of Bordeaux, in France, from 2010 to 2014, and to identify associated factors with recurrence or malignant transformation.Material and MethodsWe conducted a retrospective study in patients with a minimum follow-up of 12 months. Collected variables included characteristics of the patients (gender, age, alcohol and tobacco consumption, previous diagnosis of graft-versus-host disease, previous treatments for OPMD or for upper aerodigestive tract cancers and human immunodeficiency virus infection), characteristics of the lesions (form, colour, size, location, degree of dysplasia), laser treatment outcome (complications, recurrence, malignant transformation).ResultsTwenty-five patients were included. Mean follow-up was 28.9 months. Recurrence was observed in 11 patients (44%). Annual recurrence rate was 18.3% and annual malignant transformation rate was 1.7%. Hyperplasia without dysplasia was the only factor found to be statistically associated with recurrence.ConclusionsOur results suggest that OMPDs treated by CO2 laser vaporization have high recurrence rates, particularly those presenting hyperplasia. A standardized definition of recurrence would be necessary for inter-study comparisons. Long-term follow-up is recommended in order to detect and treat squamous cell carcinoma in its early stages. Key words:CO2 lasers, precancerous conditions, malignant transformation, oral cancer, recurrence.

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“…Three papers (9.9%) prospectively compared excision of OL by CO 2 laser versus traditional scalpel (Che et al, 2012;L opez-Jornet et al, 2013;Tambuwala et al, 2014). Table 4 summarizes these studies and the parameters used to compare the two methods (p > .05 was considered to be statistically significant).…”

Section: Comparative Studies Between Co 2 Laser and Cold Knife Surgerymentioning

confidence: 99%

Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature

Mogedas-Vegara

Hueto-Madrid

Küstner

et al. 2016

Journal of Cranio-Maxillofacial Surgery

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a b s t r a c tWe conducted a systematic review of the literature to evaluate treatment of oral leukoplakia with the carbon dioxide (CO 2 ) laser.A comprehensive search of studies published between 1981 and 2015 and listed in the PubMed (National Library of Medicine, NCBI) database yielded 378 articles which were screened in detail. Relevant studies were selected according to predetermined inclusion and exclusion criteria. A total of 33 articles met the final inclusion criteria and were analysed in detail in accordance with the PRISMA-P statement. These full-text papers were classified as synopses (n ¼ 7), recurrence and malignant transformation studies (n ¼ 17), comparative studies between CO 2 laser and cold knife surgery (n ¼ 3) and studies evaluating the efficacy of CO 2 , Nd:YAG and KTP lasers.According to the literature the CO 2 laser is the workhorse of oral leukoplakia treatment due to its effectiveness and low associated morbidity. However, randomized clinical trials are needed to compare CO 2 laser with other lasers. The results of our systematic review showed that there is no consensus regarding the factors involved in higher recurrence and malignization rates, so further studies are needed.

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Excision of Oral Leukoplakia by CO2 Lasers Versus Traditional Scalpel: A Comparative Study

Abstract: Through this study we can infer that CO2 laser supersedes conventional scalpel in terms of better intra-operative and reduced scarring. Post-operative pain and swelling after laser excision did not show any significant difference from that of scalpel.

Cited by 39 publications

References 12 publications

Comparison of the Hemodynamic Response in General Anesthesia between Patients Submitted to Skin Incision with Scalpel and CO2 Laser Using Dogs as an Animal Model. A Preliminary Study Miguel Carreira L 1, 2, 3, *, Ramalho R3 , Nielsen

Comparison of the Hemodynamic Response in General Anesthesia between Patients Submitted to Skin Incision with Scalpel and CO2 Laser Using Dogs as an Animal Model. A Preliminary Study Miguel Carreira L 1, 2, 3, *, Ramalho R3 , Nielsen

Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment

Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature

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