Excision-repair capacity of UV-irradiated strains of Escherichia coli and Streptococcus pneumoniae, estimated by plasmid recovery

Estevenon, Anne-Marie; Sicard, N

doi:10.1016/1011-1344(89)80061-2

Cited by 4 publications

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“…We have suggested that the high level of transformation could be partly correlated to the deficiency in error prone repair in pneumococci and in several other organisms (30). To evaluate further the repair capacity in pneumococci, we used a rapid assay that we had developed previously (6). It appeared that S. pneumoniae is able to carry out excision repair after UV irradiation (6).…”

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“…To evaluate further the repair capacity in pneumococci, we used a rapid assay that we had developed previously (6). It appeared that S. pneumoniae is able to carry out excision repair after UV irradiation (6). In Escherichia coli, the UvrABC system involves the products of different genes, possibly with the following functions: UvrA-UvrB complex, for search for and recognition of damaged DNA; UvrBUvrC complex, for incision; UvrD and polymerase I, for excision and replacement of the few nucleotides, with ligation being the final step (9,13,19,26,29,34).…”

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Structure of the gene complementing uvr-402 in Streptococcus pneumoniae: homology with Escherichia coli uvrB and the homologous gene in Micrococcus luteus

1992

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The repair ability for UV-induced damage observed for Streptococcus pneumoniae proceeds through a system similar to the Uvr-dependent system in Escherichia coli. The DNA sequence of a gene complementing uvr-402, a mutation conferring UV sensitivity, was determined. Alignments of the deduced amino acid sequence revealed an extensive sequence homology of 55% with the UvrB protein of E. coli and 59%o with the UvrB-homologous protein of Micrococcus luteus. Nucleotide-binding site consensus was observed. The high conservation of the uvrB-like gene among these three species suggests that the role of the UvrB protein and excision repair in general might be very important for cell survival.

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confidence: 99%