Excitability changes of trigeminal primary afferent preterminals in brain-stem nuclear complex of squirrel monkey (Saimiri sciureus).

Shende, Michael C.; King, Rylee

doi:10.1152/jn.1967.30.5.949

Cited by 23 publications

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“…In the past, pre-and post-synaptic inhibition have also been differentiated on pharmacological grounds. Relatively small intravenous doses of picrotoxin (0-2 to 1.0 mg/kg) were found to reduce presynaptic inhibition in the spinal cord (Eccles, Schmidt & Willis, 1963) in the trigeminal nucleus (Shende & King, 1967) and in the cuneate nucleus (Jabbur & Banna, 1968;Banna & Jabbur, 1969). However, much larger doses of picrotoxin in excess of 2 mg/kg, similar to those found in the present series of experiments to block the synaptically evoked depression of the glutamate-evoked discharge, have been found to block postsynaptic inhibition in occulomotor neurones (Ito, Highstein & Tsuchiya, 1970), vestibular nuclei (Ito, Highstein & Fukada, 1970), spinal motoneurones (Engberg & Thaller, 1970) and Deiters' neurones (Obata, Takeda & Shinozaki, 1970;Ten Bruggencate & Engberg, 1971).…”

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confidence: 98%

On the pharmacology of ascending, descending and recurrent postsynatic inhibition of the cuneo‐thalamic relay cells in the cat

Kelly

Renaud

1973

British J Pharmacology

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Summary1. In cats decerebrated or anaesthetized with pentobarbitone, cells of the middle third of the cuneate nucleus that were excited by tactile stimulation of the ipsilateral forelimb (responding to displacement of hairs, skin or joints) and inhibited by electrical stimulation of the contralateral pyramid, were invariably inhibited by electrical stimulation of the ipsilateral forepaw and the contralateral forelimb nerves. 2. In 50% of the cats, the cells were more fully identified by placing electrodes stereotaxically in the contralateral medial lemniscus. Recurrent inhibition was always a concomitant of the antidromic action potential. 3. The intensity and the duration of inhibition evoked by all of these pathways was totally resistant to iontophoretic and intravenous strychnine in doses at least 5 times that required to block completely the response of the same cells to iontophoretic glycine and was extremely sensitive to either iontophoretic bicuculline or picrotoxin. 4. Although the inhibition was invariably sensitive to intravenous picrotoxin, no significant change occurred in the duration or intensity of the inhibition when bicuculline was administered intravenously (5 or 6 times) as repeated doses of 0-2 mg/kg. 5. Postsynaptic inhibition in the cuneate may be mediated by y-aminobutyric acid released from the nerve terminals of a common pool of interneurones shared by ascending, descending and recurrent pathways. Since the receptors involved in this pathway are resistant to intravenous bicuculline, they may well be distinct from those responsible for changes in the primary afferent terminal excitability, usually believed to be associated with presynaptic inhibition.

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Section: )4mentioning

confidence: 98%

On the pharmacology of ascending, descending and recurrent postsynatic inhibition of the cuneo‐thalamic relay cells in the cat

Kelly

Renaud

1973

British J Pharmacology

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Efferent projections from temperature sensitive recording loci within the marginal zone of the nucleus caudalis of the spinal trigeminal complex in the cat

Burton

Craig

Poulos

et al. 1979

J of Comparative Neurology

122

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The efferent projections from nucleus caudalis of the spinal trigeminal complex in cats were studied with retrograde and anterograde axonal transport techniques combined with localization of recording sites in the thalamus and marginal zone of nucleus caudalis to innocuous skin cooling. Results showed brainstem projections from nucleus caudalis to rostral levels of the spinal trigeminal complex, to the ventral division of the principal trigeminal nucleus, the parabrachial nucleus, cranial motor nuclei 7 and 12, solitary complex, contralateral dorsal inferior olivary nucleus, portions of the lateral reticular formation, upper cervical spinal dorsal horn and, lateral cervical nucleus. Projections to the thalamus included; a dorsomedial region of VPM (bilaterally) and to the main part of VPM and PO contralaterally. Neuronal activity was recorded in the dorsomedial region of VPM to cooling the ipsilateral tongue. HRP injections in this thalamic region retrogradely labeled marginal neurons in nucleus caudalis. These results show that marginal neurons of nucleus caudalis provide a trigeminal equivalent of spinothalamic projections to the ventroposterior nucleus in cats.

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Biochemistry and Physiology of Amino Acid Transmitters

Obata

1977

Comprehensive Physiology

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Excitability changes of trigeminal primary afferent preterminals in brain-stem nuclear complex of squirrel monkey (Saimiri sciureus).

Cited by 23 publications

References 0 publications

On the pharmacology of ascending, descending and recurrent postsynatic inhibition of the cuneo‐thalamic relay cells in the cat

On the pharmacology of ascending, descending and recurrent postsynatic inhibition of the cuneo‐thalamic relay cells in the cat

Efferent projections from temperature sensitive recording loci within the marginal zone of the nucleus caudalis of the spinal trigeminal complex in the cat

Biochemistry and Physiology of Amino Acid Transmitters

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