Excitatory actions of motilin on myenteric neurons of the guinea-pig small intestine

Katayama, Yoshifumi; Ooishi, Kiyotoshi; Hirai, Keiji; Homma, Toshiyuki; Noda, Yumi

doi:10.1016/j.autneu.2005.01.005

Cited by 8 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xu et al (46) reported the guinea pig motilin amino acid sequence predicted by cDNA cloning. Although results of several electrophysiological studies on motilin using the guinea pig have been reported (22,47), to our knowledge, few morphological and molecular biological results have been reported. Moreover, Furness et al (8) showed that erythromycin-induced muscle contraction in the guinea pig is not caused through the motilin receptor, and many studies have demonstrated that guinea pig muscle preparations did not respond to motilin treatment in vitro (27,36).…”

Section: Discussionmentioning

confidence: 98%

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)

Sakahara

Xie

Koike

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus). Am J Physiol Regul Integr Comp Physiol 299: R1106 -R1113, 2010. First published August 4, 2010 doi:10.1152/ajpregu.00278.2010.-Although many studies have demonstrated the physiological action of motilin on the migrating motor complex, the precise mechanisms remain obscure. To obtain new insights into the mechanisms, we focused on the house musk shrew (Suncus murinus, suncus used as a laboratory name) as a small model animal for in vivo motilin study, and we studied the physiological characteristics of suncus gastrointestinal motility. Strain gauge transducers were implanted on the serosa of the gastric body and duodenum, and we recorded gastrointestinal contractions in the free-moving conscious suncus and also examined the effects of intravenous infusion of various agents on gastrointestinal motility. During the fasted state, the suncus stomach and duodenum showed clear migrating phase III contractions (intervals of 80 -150 min) as found in humans and dogs. Motilin (bolus injection, 100-300 ng/kg; continuous infusion, 10-100 ng · kg Ϫ1 · min Ϫ1 ) and erythromycin (80 g·kg Ϫ1 · min Ϫ1 ) induced gastric phase III contractions, and motilin injection also increased the gastric motility index in a dose-dependent manner (P Ͻ 0.05, vs. saline). Pretreatment with atropine completely abolished the motilin-induced gastric phase III contractions. On the other hand, in the free-feeding condition, the suncus showed a relatively long fasting period in the light phase followed by spontaneous gastric phase III contractions. The results suggest that the suncus has almost the same gastrointestinal motility and motilin response as those found in humans and dogs, and we propose the suncus as a new small model animal for studying gastrointestinal motility and motilin in vivo.suncus; migrating motor complex; motilin; ghrelin; gastric motility DURING A FASTED STATE, THE stomach and small intestine undergo a temporally coordinated cyclic motor pattern known as migrating motor complex (MMC) in dogs (38) and humans (44). It has been established that these coordinated contractions consist of three phases, phase I (period of motor quiescence), phase II (period of preceding irregular contractions), and phase III (period of clustered potent contractions), and the MMC is stimulated by endogenous motilin that is released in the fasted state.Motilin was originally purified from porcine intestinal mucosa in the 1970s, and its molecular structure was determined to be a 22-amino-acid polypeptide. It has been demonstrated that plasma motilin is released at ϳ100-min intervals at the interdigestive state (20,21). Physiological study of motilin in vivo has been mainly performed by using dogs and humans, and endogenous motilin and exogenous motilin have been shown to induce phase III contractions through the cholinergic pathway because atropine pretreatment completely abolished the motilin-induced contra...

show abstract

Section: Discussionmentioning

confidence: 98%

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)

Sakahara

Xie

Koike

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…The electrical stimulation of intrinsic nerves releases motilin (78). Motilin can exert excitatory effect upon the myenteric neurons in the small bowel (130). It has been demonstrated that atropine, unlike hexamethonium, blocked motilin release evoked by the carbachol since the muscarinic receptors are present on the motilin cells (321).…”

Section: Motilinmentioning

confidence: 99%

Importance of the enteric nervous system in the control of the migrating motility complex

Romanski

2017

Acta Physiol Hung

View full text Add to dashboard Cite

The migrating motility complex (MMC), a cyclical phenomenon, represents rudimentary motility pattern in the gastrointestinal tract. The MMC is observed mostly in the stomach and gut of man and numerous animal species. It contains three or four phases, while its phase III is the most characteristic. The mechanisms controlling the pattern are unclear in part, although the neural control of the MMC seems crucial. The main goal of this article was to discuss the importance of intrinsic innervation of the gastrointestinal tract in MMC initiation, migration, and cessation to emphasize that various MMC-controlling mechanisms act through the enteric nervous system. Two main neural regions, central and peripheral, are able to initiate the MMC. However, central regulation of the MMC may require cooperation with the enteric nervous system. When central mechanisms are not active, the MMC can be initiated peripherally in any region of the small bowel. The enteric nervous system affects the MMC in response to the luminal stimuli which can contribute to the initiation and cessation of the cycle, and it may evoke irregular phasic contractions within the pattern. The hormonal regulators released from the endocrine cells may exert a modulatory effect upon the MMC mostly through the enteric nervous system. Their central action could also be considered. It can be concluded that the enteric nervous system is involved in the great majority of the MMC-controlling mechanisms.

show abstract

“…Direct evidence for the existence of motilin and ghrelin in guineapig myenteric neurons suggested that both peptides may play a role in the activation of the enteric nervous system and hence in the regulation of gastrointestinal motility [28]. That motilin receptors were expressed primarily on NOS neurons requires further study in order to determine how this relates to its prokinetic action, in particular since motilin activates few myenteric neurons [29]. Part of the explanation may be the finding that motilin exerts a presynaptic inhibitory effect on ganglionic transmission in the myenteric plexus of the guinea pig ileum [30].…”

Section: Other Channels and Receptorsmentioning

confidence: 99%

Enteric nervous system

Grundy

Schemann²

2006

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

show abstract

Excitatory actions of motilin on myenteric neurons of the guinea-pig small intestine

Cited by 8 publications

References 18 publications

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)

Physiological characteristics of gastric contractions and circadian gastric motility in the free-moving conscious house musk shrew (Suncus murinus)

Importance of the enteric nervous system in the control of the migrating motility complex

Enteric nervous system

Contact Info

Product

Resources

About