Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats

Lawand, Nada; Willis, William D.; Westlund, Karin N.

doi:10.1016/s0014-2999(97)00072-1

Cited by 220 publications

(145 citation statements)

References 40 publications

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“…Ionotropic and metabotropic glutamate receptors are present on membranes of unmyelinated peripheral axons and axon terminals in the skin (Carlton et al, 1995;Zhou et al, 2001b), and peripheral inflammation increases the proportions of both unmyelinated and myelinated nerves expressing ionotropic glutamate receptors . Local injections of NMDA and non-NMDA glutamate receptor agonists to the rat hindpaw (Jackson et al, 1995;Zhou et al, 1996) or knee joint cavity (Lawland et al, 1997) enhance pain behaviors generating hyperalgesia and allodynia. Intraplantar injection of metabotropic glutamate receptor agonists produces similar actions (Walker et al, 2001;Zhou et al, 2001b).…”

Section: F Glutamate Receptor Antagonistsmentioning

confidence: 99%

Topical and Peripherally Acting Analgesics

2003

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Section: F Glutamate Receptor Antagonistsmentioning

confidence: 99%

Topical and Peripherally Acting Analgesics

2003

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“…41 Intraarticular EAA injection resulted in thermal hyperalgesia and mechanical allodynia, which were attenuated by local injection of N-methyl-D-aspartate (NMDA) or non-NMDA receptor antagonists. 27 Lawand et al 26 also demonstrated that intraarticular lidocaine injection prevented glutamate release and nociceptors sensitization of inflammatory joints. Moreover, in inflamed arthritic knees, an increase of glutamate concentration was observed not only in the axons in the inflamed region, 25 but also in the synovial fluid.…”

Section: Discussionmentioning

confidence: 96%

“…25 A potential peripheral action of glutamate has been suggested, as increased glutamate levels are seen in the peripheral tissues in acute and chronic inflammation in both animals and humans. 23,26,27 Increased glutamate levels in the knee joint and medial articular nerve are seen after induction of arthritis in the rat. 26 We previously reported that glutamate and aspartate levels were significantly increased in dialysates of anterior cruciate ligament-transected (ACLT) knees, 28 suggesting a role of EAA in early OA development.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament‐transected knee: Association with excitatory amino acid release in the joint dialysate

Jean

Wen

Chang

et al. 2006

Journal Orthopaedic Research

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We previously reported increased release of the excitatory amino acid (EAA) neurotransmitters, glutamate and aspartate, during the early stage of experimental osteoarthritis (OA). Our present objective was to study the effect of intraarticular injection of hyaluronic acid (HA) on OA development, and to analyze concomitant changes in EAA levels in dialysates of anterior cruciate ligament-transected (ACLT) knee joints. OA was induced in Wistar rats by ACLT of one hindlimb; the knee of the other hindlimb was used as the sham-operated control. HA group (n ¼ 12) were injected intraarticularly in the ACLT knee with 1 mg of HA once a week for 5 consecutive weeks, starting at 8 weeks after surgery. Saline group (n ¼ 12) were injected as above with normal saline. The sham-operated group, underwent arthrotomy, but not ACLT, and received no treatment (n ¼ 14). Twenty weeks after surgery, knee joint dialysates were collected by microdialysis and EAA levels assayed by high-performance liquid chromatography, and gross morphological examination and histopathological evaluation were performed on the medial femoral condyles and synovia. Rats receiving intraarticular HA injections showed a significantly lower degree of cartilage degeneration on the medial femoral condyle at both the macroscopic level and on the Mankin grading scale than rats receiving saline injections. Intraarticular HA treatment also suppressed synovitis. Moreover, glutamate and aspartate levels were significantly reduced in the HA group compared to the saline group. Intraarticular injection of HA limits articular cartilage and synovium damage and OA formation, and, in parallel, reduces EAA levels in ACLT joint dialysates. This study suggests that the underlying mechanism of the anti-inflammatory effect of HA is to inhibit glutamate and aspartate release in ACLT knee joints, which attenuates the early development of OA. ß

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“…[25][26][27] Peripheral injection of NMDA receptor antagonist attenuates pain associated with neuropathic or inflammatory origin. [28][29][30][31][32] Thus, the involvements of NMDA receptors are expected in the peripheral processing of nociception.…”

Section: Discussionmentioning

confidence: 99%

N-methyl-D-aspartate receptors mediate Mesobuthus tamulus venominduced vasosensory reflex responses in anesthetized rats

Singh¹,

Deshpande²

2017

Natl J Physiol Pharm Pharmacol

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Background:The autonomic changes and cardiorespiratory changes seen in vascular disorders are suggested to be mediated reflexly by the activation of perivascular nociceptors. The role of prostaglandins, vanilloid receptor 1, 5-hydroxytryptamine type 3, and kinin receptors is well established. Aims and Objectives: This study was conducted to understand the role of N-methyl-D-aspartate (NMDA) receptor in modulating vasosensory reflex responses evoked by Mesobuthus tumulus venom. Materials and Methods: Healthy male albino rats were anesthetized with an intra-peritoneal injection of urethane (1.5 g/kg). Tracheostomy was performed to keep the airway patent. Femoral artery was cannulated proximally as well as distally to record the blood pressure (BP) and to inject the chemicals, respectively. The effect of venom on BP, heart rate (HR), respiratory rate, and minute ventilation was recorded for 60 min at every 5 min and presented as mean ± standard error of mean. Results: Intra-arterial injection of venom produced immediate hyperventilatory response (increase of 41.6%), followed by hypoventilatory response (decrease of 40.1%), and finally sustained hyperventilatory response (increase of 53%) which was observed up to 60 min. The hypertensive response started at 40 s, peaking at 5 min (increase of 48%), and remained above the initial level subsequently. The bradycardiac response began around 5 min, peaking at 25 min (decrease of 50% in HR), and remained at that level up to 60 min. In 2-amino 5-phosphonovaleric acid (NMDA receptor antagonist) pre-treated group, the venom-induced cardiovascular responses (mean arterial pressure and HR) were markedly attenuated in comparisons to the venom only group but not the respiratory responses. Conclusions: The data provide evidence for the involvement of NMDA receptors in producing the venom-induced vasosensory reflex responses modulating the cardiovascular parameters in anesthetized rats.

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Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats

Cited by 220 publications

References 40 publications

Topical and Peripherally Acting Analgesics

Topical and Peripherally Acting Analgesics

Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament‐transected knee: Association with excitatory amino acid release in the joint dialysate

N-methyl-D-aspartate receptors mediate Mesobuthus tamulus venominduced vasosensory reflex responses in anesthetized rats

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