2002
DOI: 10.1124/jpet.300.2.597
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Excitatory Mechanism of Deflationary Slowly Adapting Pulmonary Stretch Receptors in the Rat Lung

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Cited by 10 publications
(6 citation statements)
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“…In our previous study, 11% of slowly adapting units responded to lung deflation with removal of PEEP (20). This type of unit has been studied extensively in the rabbit (1,11,14), as well as other animals such as cats (1,9,19), dogs (2), guinea pigs, (10) rats (3,6,12,17), and mice (25). Airway sensory units can be slowly or rapidly adapting to either lung inflation or deflation.…”
Section: Discussionmentioning
confidence: 97%
“…In our previous study, 11% of slowly adapting units responded to lung deflation with removal of PEEP (20). This type of unit has been studied extensively in the rabbit (1,11,14), as well as other animals such as cats (1,9,19), dogs (2), guinea pigs, (10) rats (3,6,12,17), and mice (25). Airway sensory units can be slowly or rapidly adapting to either lung inflation or deflation.…”
Section: Discussionmentioning
confidence: 97%
“…The increases in SAR activity during lung inflation are well known to be proportional to those in the inflation volume (1-3 V T ) of the respirator, corresponding with the values for P T , in rabbits (Matsumoto et al 1998) and rats (Matsumoto et al 2000b(Matsumoto et al , 2002. The inflation volume to produce approximately 15 cmH 2 O ranged from 10 to 12 ml.…”
Section: Discussionmentioning
confidence: 98%
“…The SARs were identified on the bases of their firing behavior during inflation, as follows: (1), the increases in SAR activity were proportional to those in the inflation volume of the respirator and (2), the discharges of SARs continued as long as the tracheal tube was occluded in a hyperinflated condition. As described in previous studies (Tsubone 1986;Bergren and Peterson 1993;Matsumoto et al 2002Matsumoto et al , 2006, we determined the adaptation index (AI) of SARs during the maintained inflation for 5 s; we then substracted the average frequency during 1 s of maintained inflations from the peak frequency of the receptors during the procedures and then divided this by the peak frequency. The values for the AI of SARs were below 50%, as reported by Bergren and Peterson (1993) and Matsumoto et al (2002).…”
Section: Methodsmentioning
confidence: 99%
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“…The fiber activity after drug application was quantified by subtracting background discharges from the evoked activities. We determined the adaptation index (AI) of unit activity on the peak frequency of the unit minus the average frequency during the second of the procedures (from 2 to 3 s) and then divided this by the peak frequency, using the same method as described in previous studies ( Matsumoto et al, 2002 ) . This number was multiplied by 100 to obtain a percentage adaptation.…”
Section: Methodsmentioning
confidence: 99%