Excito-repellent activity of β-caryophyllene oxide against Aedes aegypti and Anopheles minimus

Abstract

 β-caryophyllene oxide had stronger repellent and irritant effect than DEET  Ae. albopictus was more sensitive to β-caryophyllene oxide than An. dirus while, knockdown responses (37%) were observed in An. dirus exposed to 1% β-caryophyllene oxide in the contact trial.  β-caryophyllene oxide did not show any phototoxic activity.  None of the tested β-caryophyllene oxide induced a significant increase of micronucleated cells with or without metabolic activation.  β-Caryophyllene oxide could be considered as a safe repellent, effective against mosquitoes.

Volatile chemical composition of Colombian Piper gorgonillense Trel. & Yunck. essential oil and its repellent and fumigant activity against Tribolium castaneum Herbst

“…b-Caryophyllene has shown repellent activity against Aedes aegypti and Anopheles minimus (Nararak et al, 2019), as well as against Sitophilus granarius (Plata et al, 2018). In the study reported by Parisotto et al (2020), β-caryophyllene acted as a powerful anti-inflammatory agent and demonstrated efficiency in the repair of skin tissue; β-caryophyllene provided anti-inflammatory and antiedemagnetic activity in in vivo tests of acute and chronic inflammation through a series of laboratory tests (De Oliveira-Tintino et al, 2018).…”

Chemical Composition and Antioxidant Activity of Essential Oils from Leaves of Two Specimens of Eugenia florida DC.

“…The ( E )-caryophyllene, at a lower content (2.35%), was found in the essential oil of the EflB specimen. Studies report that caryophyllene oxide has insecticidal activity against the Aedes aegypt vector, an important vector of diseases such as dengue, zika and chikungunya [ 39 ]. This compound also presents gastroprotective potential [ 40 ] and antiviral potential [ 41 ], as well as potential activity against leishmania [ 42 ].…”

Phytol, (E)-nerolidol and spathulenol from Stevia rebaudiana leaf essential oil as effective and eco-friendly botanical insecticides against Metopolophium dirhodum

“…aegypti. (USDA strain) and Anopheles minimus (KU strain) mosquitoes, performing better than the commercial repellent N,N-diethyl-meta-toluamide (DEET) (Nararak et al, 2019). Caryophyllene oxide, which is a main component also of the Origanum vulgare L. EO, led to 100 % repellence against Tribolium castaneum (Herbst) beetles when tested at 0.03 mg cm −2 (Kim et al, 2010).…”