Excitotoxic Lesions of the Gustatory Thalamus Spare Simultaneous Contrast Effects but Eliminate Anticipatory Negative Contrast: Evidence Against a Memory Deficit.

Reilly, Steve; Bornovalova, Marina A.; Trifunovic, Radmila

doi:10.1037/0735-7044.118.2.365

Cited by 26 publications

(30 citation statements)

References 46 publications

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“…This effect, called the anticipatory contrast effect, is observed when saccharin is paired with drugs of abuse or when a weaker saccharin solution is paired with a subsequent stronger solution (Grigson and Freet 2000;Schroy et al 2005). Additional support comes from the observation that ibotenic acid lesions of the gustatory thalamus disrupt the avoidance of the saccharin produced by injection of drugs of abuse, but not by injection of lithium chloride (Grigson and Freet 2000;Schroy et al 2005;Reilly et al 2004). Rabin et al (1998) have reported similar results following exposure to heavy particles.…”

Section: Discussionsupporting

confidence: 54%

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Carrihill-Knoll

Rabin

Shukitt‐Hale

et al. 2007

AGE

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Exposure to 56 Fe particles produces changes in dopaminergic function and in dopaminedependent behaviors, including amphetamine-induced conditioned taste aversion (CTA) learning. Because many of these changes are characteristic of the changes that accompany the aging process, the present study was designed to determine whether or not there would be an interaction between age and exposure to 56 Fe particles in the disruption of an amphetamine-induced CTA. One hundred and forty F-344 male rats 2-, 7-, 12-, and 16-months old, were radiated with 56 Fe particles (0.25-2.00 Gy, 1 GeV/n) at Brookhaven National Laboratory. Three days following irradiation, the rats were tested for the effects of radiation on the acquisition of a CTA produced by injection of amphetamine (3 mg/kg, i.p.). The main effect of age was to produce a significant decrease in conditioning day sucrose intake; there was no affect of age on the acquisition of the amphetamine-induced CTA. Exposing rats to 56 Fe particles disrupted the acquisition of the CTA produced by injection of amphetamine only in the 2-month-old rats. These results do not support the hypothesis of an interaction between age and exposure to 56 Fe particles in producing a disruption of amphetamine-induced CTA learning. As such, these results suggest that the aging produced by exposure to 56 Fe particles may be endpoint specific.

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Section: Discussionsupporting

confidence: 54%

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Carrihill-Knoll

Rabin

Shukitt‐Hale

et al. 2007

AGE

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“…The suppressive effects of cocaine and sucrose, but not LiCl, are augmented in rats with a history of chronic morphine treatment [57]. Finally, bilateral lesions of the gustatory thalamus or gustatory cortex disrupt the suppressive effects of morphine, cocaine, and sucrose, but have no impact on the development of a LiCl-induced CTA [58][59][60][61][62][63][64][65]. Taken together, the data confirm that drug-induced suppression of CS intake is not mediated by a conditioned taste aversion like that induced by the aversive agent.…”

Section: The Model: Experimenter Delivered Drugmentioning

confidence: 99%

Reward comparison: the Achilles’ heel and hope for addiction

Grigson

2008

Drug Discovery Today: Disease Models

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In the words of the late Charles Flaherty, reward comparison is commonplace. Rats and man, it appears, compare all rewards and this capacity likely contributes to our ability to select the most appropriate reward/behavior (food, water, salt, sex), at the most ideal level (e.g., a certain sweetness), at any given time. A second advantage of our predisposition for reward comparison is that the availability of rich alternative rewards can protect against our becoming addicted to any single reward/behavior. Thus, the potential protective effects of natural rewards/enrichment are addressed. Despite this, behavior can become inflexible when, through the development of addiction, stress, drug, or cues elicit craving, withdrawal, and ultimately, drug-seeking. Drug-seeking corresponds with a 'window of inopportunity', when even potent natural rewards have little or no impact on behavior. During this time, there is a unitary solution to the need state, and that solution is drug. The present animal model explores this 'window of inopportunity' when natural rewards are devalued and drug-seeking is engaged and considers a mode of possible intervention.

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“…Thorough reviews of earlier studies suggested that the claim of the involvement of VPMpc in taste preference, sodium appetite, and CTA were derived from the lesions that were misplaced, inordinately large, or destroyed fibers of passage (58,60,69). More recent investigations indicated that the VPMpc is instead involved in more complex gustatory information processing tasks, e.g., anticipatory contrast effect in which rats reduce intake of an otherwise palatable (saccharin) solution when presentation of this solution predicts access to a more preferred (sucrose) solution over repeated daily pairings (18,61,67).…”

mentioning

confidence: 99%

Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

Mao¹,

Cho²,

Li³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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(VPMpc) is positioned at the key site between the gustatory parabrachial nuclei (PbN) and the gustatory cortex for relaying and processing gustatory information via the thalamocortical pathway. Although neuroanatomical and electrophysiological studies have provided information regarding the gustatory projection from PbN to VPMpc, the exact relationship between PbN and VPMpc, especially the efferent projection involving VPMpc to PbN, is obscure. Here we investigated the reciprocal connection between these two gustatory relays in urethaneanesthetized hamsters. We recorded from 114 taste-responsive neurons in the PbN and examined their responsiveness to electrical stimulation of the VPMpc bilaterally. Stimulation of either or both of the ipsilateral or contralateral VPMpc antidromically activated 109 gustatory PbN neurons. Seventy-two PbN neurons were antidromically activated after stimulation of both sides of the VPMpc, indicating that taste neurons in the PbN project heavily to the bilateral VPMpc. Stimulation of VPMpc also orthodromically activated 110 of PbN neurons, including 106 VPMpc projection neurons. Seventyeight neurons were orthodromically activated bilaterally. Among orthodromic activations of the PbN cells, the inhibitory response was the dominant response; 106 cells were inhibited, including 10 neurons that were also excited contralaterally, indicating that taste neurons in the PbN are subject to strong inhibitory control from VPMpc. Moreover, stimulation of VPMpc altered taste responses of the neurons in the PbN, indicating that VPMpc modulates taste responses of PbN neurons. These results may provide functional insight of neural circuitry for taste processing and modulation involving these two nuclei.central gustatory pathway; pons; electrophysiology THE PARABRACHIAL NUCLEI (PbN) and the parvicellular part of the ventroposteromedial nucleus of the thalamus (VPMpc) are the second and tertiary central relays for taste information processing in rodents, respectively (4,13,17,28,45,49,51). Gustatory information elicited from the tongue and oropharyngeal cavity is initially carried to the rostral portion of the nucleus of the solitary tract (NST) by the VIIth, IXth, and Xth cranial nerves, and these terminals are distributed in a topographic fashion with rostral-caudal sequence in the rostral NST (2,9,23,24,89). From the NST, ascending gustatory fibers project to third-order taste cells within the PbN of the pons (7,22,42,46,(53)(54)(55)87). Two separate routes carry taste information from the PbN further to the forebrain taste areas and cortex: the ventral forebrain pathway that involves the central nucleus of the amygdala (CeA), the lateral hypothalamus (LH), the bed nucleus of the stria terminalis (BNST), the substantia innominata (3,12,16,21,31,33,34,41,47,63,64,71); and the thalamocortical pathway that is characterized by the involvement of the bilateral VPMpc, which, in turn, carries taste information to the gustatory cortex (GC) (5,25,45,48,51).The PbN is a critical neural substrate for a number...

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Excitotoxic Lesions of the Gustatory Thalamus Spare Simultaneous Contrast Effects but Eliminate Anticipatory Negative Contrast: Evidence Against a Memory Deficit.

Cited by 26 publications

References 46 publications

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles

Reward comparison: the Achilles’ heel and hope for addiction

Modulation of activity of gustatory neurons in the hamster parabrachial nuclei by electrical stimulation of the ventroposteromedial nucleus of the thalamus

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