1992
DOI: 10.1016/0006-8993(92)91499-5
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Excitotoxin paraventricular nucleus lesions: stress and endocrine reactivity and oxytocin mRNA levels

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Cited by 55 publications
(41 citation statements)
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“…These results are in line with the notion that the release of OXY from hypothalamic PVN neurons is involved in the negative regulation of food intake and body weight and participates to the hypophagic effects of several endogenous and exogenous compounds, such as leptin, CCK, and oleoylethanolamide [27,28,[49][50][51]. Moreover, the OXY system is also stressresponsive; in fact, an increase of OXY concentrations at both plasma and PVN level has been observed after different kinds of stress, such as immobilization, footshock, and shaking [41,[52][53][54]. In agreement with previous observations, in the present study, the increase of OXY mRNA observed in CPD/CD mice might be interpreted as a stressrelated response that is causing also the decrease of food intake and body weight in this group, due to the effects of OXY on energy metabolism.…”
Section: Discussionmentioning
confidence: 60%
“…These results are in line with the notion that the release of OXY from hypothalamic PVN neurons is involved in the negative regulation of food intake and body weight and participates to the hypophagic effects of several endogenous and exogenous compounds, such as leptin, CCK, and oleoylethanolamide [27,28,[49][50][51]. Moreover, the OXY system is also stressresponsive; in fact, an increase of OXY concentrations at both plasma and PVN level has been observed after different kinds of stress, such as immobilization, footshock, and shaking [41,[52][53][54]. In agreement with previous observations, in the present study, the increase of OXY mRNA observed in CPD/CD mice might be interpreted as a stressrelated response that is causing also the decrease of food intake and body weight in this group, due to the effects of OXY on energy metabolism.…”
Section: Discussionmentioning
confidence: 60%
“…This is not surprising since emotional stress is not associated with intranuclear or peripheral release of VP. Stress was found to increase intranuclear release of oxytocin (OT) (Callahan et al, 1989;Callahan et al, 1992;Nishioka et al, 1998), and a role for the oxytocin receptor (OTR) in the stress response was further supported by pharmacological and genetic modulation of OTR in the PVN (Lozić et al, 2014). Also, we have shown that during exposure of rats to air-jet stress, selective blockade of central VP receptors do not affect the response of the hypothalamo-pituitary axis as judged by the concentration of blood corticosterone (Stojičić et al, 2008), suggesting that VP released into the portal circulation during air-jet stress does not modulate ACTH release into the blood stream.…”
Section: Discussionmentioning
confidence: 99%
“…Although the physiologic effects of oxytocin in smooth muscle contraction are well established (Mironneau, 1976;Sakai et al, 1981;Maigaard et al, 1986;Oishi et al, 1991;Duridanova et al, 1997), numerous studies reported that oxytocin plays a major regulatory role in complex neural functions including memory and behavior (Van Wimersma Greidanus et al, 1986;Hughes et al, 1987;Herbert, 1994;Frasch et al, 1995;Insel et al, 1997;Engelmann et al, 2000;Argiolas and Melis, 2004;de Oliveira et al, 2007). Moreover, several data indicate that oxytocin is also involved in the regulation of the stress response in numerous species including humans (Carter and Lightman, 1987a,b;Callahan et al, 1989Callahan et al, , 1992Sanders et al, 1990;Jezova et al, 1995;Windle et al, 1997Windle et al, , 2004Engelmann et al, 1999;Chatterton et al, 2000;Douglas et al, 2000).…”
Section: Introductionmentioning
confidence: 94%
“…PVN attenuates stress-induced tachycardia in rat (Callahan et al, 1992), the integrity of oxytocinergic neurons in the PVN appears to be crucial in the response to stress. In contrast to these findings, a number of animal studies suggest that oxytocin plays a major role in stress response attenuation (Uvnas-Moberg, 1997;Cook, 1997;Windle et al, 1997Windle et al, , 2004Legros, 2002).…”
Section: Introductionmentioning
confidence: 98%
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