Exclusive and Common Subsets of Zika Virus Polyprotein Mutants

A Bioinformatic Glimpse of Human-Origin Zika Virus Polyprotein

“…H was determined for all amino acid positions in the set of polyproteins isolated from humans, and independently for all amino acid positions in the set of polyproteins isolated from mosquitos. Amino acid positions where H>0.0 in the polyprotein were classified and sorted into Exclusive (x) and Common (c) subsets as previously described [6], depending upon whether (1) a positive H value occurred only at amino acid positions in ZIKV polyproteins obtained exclusively from human hosts or whether (2) the positive H value occurred at amino acid positions in ZIKV polyproteins common both to human hosts and to Aedes species of vector mosquitos.…”

“…It was recently reported that the set of mutations in polyproteins obtained from ZIKV isolated from humans can be partitioned into two subsets [6]: Exclusive (x) subset and Common (c) subset. Mutations in the x subset occur exclusively in the human host.…”