Exclusive B‐cell phenotype of primary prostatic lymphomas: a potential role of chronic prostatitis

Abstract

Aims Primary prostatic lymphomas (PPL) is exceedingly rare. The aim of this study was to investigate the largest series of PPL obtained from a nationwide expert pathologist network, and thus try to understand the pathophysiology of these tumours. Methods and results Up to 66 000 lymphoma cases have been collected and submitted for central expert review by the French Lymphopath network. We confirm the low frequency of PPL (n = 77; 0.12%), all cases being of B‐cell origin. Diffuse large B‐cell lymphoma and small lymphocytic lymphoma were the most frequent subtypes, comprising 31% and 26% of cases respectively, followed by mucosa‐associated lymphoid tissue (MALT)/lymphoplasmacytic lymphoma (19%), follicular lymphoma (12%), mantle cell lymphoma (6%), Burkitt lymphoma (4%), and unclassified lymphoma (1%). Clinical data obtained in 25 cases suggests that PPLs are rather indolent tumours. Our hypothesis for B‐cell recruitment in the prostatic tissue was derived from the observation in chronic inflammation (prostatitis) of frequent heterotopic proliferation of high endothelial venules (HEVs). The latter are dedicated to lymphocyte entry into secondary lymphoid organs, here putatively driving circulating clonal B‐lymphocytes from the blood into the inflamed prostate. This may account for the relatively high incidence of small lymphocytic lymphoma consistently reported in series of primary or secondary prostatic lymphoma. As in other organs or glands, chronic inflammation may promote antigen‐dependent intraprostatic MALT lymphoma and diffuse large B‐cell lymphoma development. Conclusions PPLs are exclusively of B‐cell origin, and chronic inflammation resulting from the proliferation of high endothelial venules could play some role in their development.

The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b

“…Moreover, the abundance of these elements is also linked to the severity of chronic prostatitis. 16 This study showed that the combination of tamsulosin hydrochloride and terazosin can effectively reduce the number of WBC in patients' plasma and increase the number of lecithin bodies in patients' EPS, which fully shows that the combination therapy can significantly improve the symptoms of patients.…”

Primary follicular lymphoma of the prostate presenting with elevated PSA and a PI-RADS 3 lesion on MRI: A case report

“…Suspicious findings on multiparametric MRI culminated in prostate biopsy, which demonstrated primary follicular lymphoma of the prostate. This particular histologic type makes up only 12% of primary prostatic lymphoma, 3 and has been rarely reported in the literature. In addition, several other aspects of this case make it unique.…”

“…Other reported subtypes include small lymphocytic lymphoma, mucosa-associated lymphoid tissue, follicular lymphoma, mantle cell lymphoma, and Burkitt lymphoma. 3 …”