Synthetic phenolic antioxidants (SPAs)
are a group of ubiquitous
contaminants with multiple toxicities. However, current knowledge
on the occurrence of SPAs in baby food and associated infant exposure
is lacking. Herein, we analyzed three categories of baby food from
China: infant formula, cereal, and puree, for a broad suite of 11
traditional and 19 novel SPAs. In addition to 11 traditional SPAs,
up to 13 novel SPAs were detected in the baby food samples. The median
concentrations of novel SPAs for infant formula, cereal, and puree
were 604, 218, and 24.1 ng/g, respectively, surpassing those of traditional
SPAs (53.4, 62.1, and 10.0 ng/g). The prevalent SPAs in the samples
were butylated hydroxytoluene, 2,4-di-tert-butylphenol,
pentaerythritol tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]
(AO 1010), and octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)
propionate (AO 1076). Source analysis indicated that the prevalence
of these four SPAs in baby food was associated with contamination
of packaging materials, mechanical processing, or raw ingredients.
Migration experiments demonstrated that contamination of plastic packaging
constituted an important source. Exposure assessment suggested that
there may be no appreciable health risk posed by the SPAs in baby
food. Even so, baby food consumption was still a dominant pathway
for infant exposure to SPAs, with a higher contribution than breast
milk consumption, dust ingestion, dermal dust absorption, and air
inhalation, which requires special attention.