Excretion in the airway (I). Effect of autonomic drugs.

Koda, Akihide; Inoue, Kichiro; Nakamura, Kazumitsu; Mori, Hiroshi

doi:10.1254/fpj.74.317

Folia Pharmacologica Japonica

1978

DOI: 10.1254/fpj.74.317

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Excretion in the airway (I). Effect of autonomic drugs.

Akihide Koda¹,

Kichiro Inoue²,

Kazumitsu Nakamura³

et al.

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1980

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Cited by 3 publications

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“…continuously for 4 weeks on the airway excretion was examined in rats. Increases were observed in the protein level and viscosity of the excretion, however, these increases were far less than seen in cases of continuous dosing of isoproterenol (4). Thus, compound 1 does not appear to have a harmful effect on the airway excretion.…”

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Effect of 1,3-bis(2-phenyl-4-chromenon-5-yl)-2-ol on experimental asthma in guinea pigs.

et al. 1980

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We have already reported the inhibition of homologous passive cutaneous anaphylaxis (PCA) by 14 newly synthesized compounds related to the chemical structure of disodium cromoglycate (1). Since 1, 3-bis(2-phenyl-4-chromenon-5-yl)-2-o1 (compound 1) showed the most potent inhibition of PCA when given orally, the effect of the agent on experimentally-induced atopic type of asthma in guinea pigs was examined.According to Levine et al. (2), antiserum containing homocytotropic antibody was obtained from guinea pigs which had been immunized with benzylpenicilloyl bovine 7-globulin (BPO83•BGG) mixed with alumina as an adjuvant and which was given i.p. 8 to 12 times monthly. Sera collected from each animal 30 days after the last injection were pooled and frozen at -20'C until use. The antibody titer of this serum was 1 : 1024, as estimated by 7-day homologous PCA. Male Hartley guinea pigs weighing about 350 g were passively sensitized by an intracardiac injection of the antiserum in a dose of 0.5 ml/ animal. After 48 hr the animals were anesthesized with urethane and given 0.2 mg/kg of benzylpenicilloyl bovine serum albumin (BPO23-BSA) i.v. as a hapten-specific antigen. The change of respiration was similar to that seen in the case of asthmatic attacks in humans.The expiratory disorder was quite evident and was prolonged considerably as compared to that induced in rats (3). Thus we chose this model for experiments on the atopic type of asthma.Compound 1 was administered in doses of 1.0 to 20 mg/kg p.o. to guinea pigs 2 hr prior to challenge. The animals were deprived of food for 24 hr before the drug treatment, but water was provided ad libitum. In the case of 1.0 mg/kg, antigen-induced decrease in the rate of respiration showed a tendency toward inhibition while that in the volume of respiration was significantly inhibited. The ratio of the time required to expire against that to inspire (Ex/In) was increased by the antigen treatment 20 to 30% of the value seen before challenge. This increase in the ratio was slightly inhibited by 1.0 mg/kg of the agent. All such changes in the respiration were significantly inhibited by 10 to 20 mg/kg of the agent, as shown in Fig. 1.To determine the duration of the inhibitory activity of compound 1 on the

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confidence: 85%

Effect of 1,3-bis(2-phenyl-4-chromenon-5-yl)-2-ol on experimental asthma in guinea pigs.

et al. 1980

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Effect of 1, 3-Bis (2-Phenyl-4-Chromenon-5-Yl)-2-Ol on Experimental Asthma in Guinea Pigs

Koda

Sakamoto

Nakamura

et al. 1980

Japanese Journal of Pharmacology

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Effects of SS320A, a New Cysteine Derivative, on the Change in the Number of Goblet Cells Induced by Isoproterenol in Rat Tracheal Epithelium

Takahashi¹,

Mizuno

Ohno

et al. 1998

Japanese Journal of Pharmacology

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We examined the effects of SS320A ((-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid), a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium. Four types of goblet cells were characterized in tracheal epithelium according to their size and staining affinity with Alcian blue (AB) / periodic acid Schiff (PAS). When each rat was given a single daily injection of isoproterenol (0.05 mg/kg, i.p.) for 14 days, a significant increase was observed in AB/PAS-positive cells that were recognizable as goblet cells in tracheal epithelium. When SS320A (10-100 mg/kg, p.o.) or propranolol (1 mg/kg, s.c.) was administered before each injection of isoproterenol, the increase in the number of goblet cells induced by isoproterenol was significantly inhibited. There was no difference between male and female rats with regard to this inhibitory action. On the other hand, ambroxol, bromhexine, L-cysteine ethyl ester and S-carboxymethylcysteine (100 mg/kg, p.o., respectively), which are used as expectorants, had no inhibitory effects on the isoproterenol-induced change in the number of goblet cells. Four metabolites (M1-M4) of SS320A in rats also failed to inhibit the change induced by isoproterenol. These data suggest that SS320A itself may have a beneficial effect against mucus hypersecretion in chronic respiratory diseases.

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Excretion in the airway (I). Effect of autonomic drugs.

Cited by 3 publications

References 0 publications

Effect of 1,3-bis(2-phenyl-4-chromenon-5-yl)-2-ol on experimental asthma in guinea pigs.

Effect of 1,3-bis(2-phenyl-4-chromenon-5-yl)-2-ol on experimental asthma in guinea pigs.

Effect of 1, 3-Bis (2-Phenyl-4-Chromenon-5-Yl)-2-Ol on Experimental Asthma in Guinea Pigs

Effects of SS320A, a New Cysteine Derivative, on the Change in the Number of Goblet Cells Induced by Isoproterenol in Rat Tracheal Epithelium

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