Excretion of alpha-tocopherol into human seminal plasma after oral administration

Moilanen, J.; Hovatta, Outi

doi:10.1111/j.1439-0272.1995.tb01083.x

Cited by 53 publications

(29 citation statements)

References 17 publications

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“…Only four of these studies [28][29][30][31] found little or no effect on semen parameters, whereas beneficial effects were reported in the remaining 18 studies. 8,19,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] In vitro studies.…”

Section: Vitamin Ementioning

confidence: 99%

“…In 1995, Kessopoulou et al 28 and Moilanen and Hovatta 29 administered vitamin E 600 mg day 21 for 3 months and 600, 800 or 1200 mg day 21 for 3 weeks, respectively, finding increased concentrations of vitamin E in plasma and semen but no changes in semen parameters. In 1996, Geva et al 30 conducted a prospective study on 15 antiretroviral therapy patients, in which the administration of 200 mg day 21 for 3 months produced no changes in sperm morphology.…”

Section: Vitamin Ementioning

confidence: 99%

“…Kessopoulou et al, 1995 28 No effects (600 mg day 21 for 3 months, in vivo) Moilanen and Hovatta, 1995 29 No effects (600-1200 mg day 21 for 3 weeks, in vivo) Geva et al, 1996 30 No effects (200 mg day 21 for 3 months, in vivo) Vezina et al, 1996 35 Increased motility, morphology, viability; no effects on concentration (400 mg day 21 1 100-200 mg day 21 Se for 6 months, in vivo) Suleiman et al, 1996 36 Increased pregnancy rate, increased motility, reduced lipid peroxidation (300 mg day 21 for 6 months, in vivo) Kodama et al, 1997 37 Increased concentration, reduced DNA damage (200 mg vitamin C1200 mg vitamin E1GSH 400 mg every day for 2 months, in vivo) Hughes et al, 1998 38 Reduced DNA damage after Percoll preparation (30-60 mmol l 21 vitamin E, in vitro) Hughes et al, 1998 38 Increased DNA damage after Percoll preparation (300-600 mmol l 21 vitamin C1 30-60 mmol l 21 vitamin E, in vitro) Twigg et al, 1998 19 No effects on NADPH-induced lipid peroxidation (1 mmol l 21 , in vitro) Donnelly et al, 1999 39,40 Reduced H 2 O 2 -induced ROS production and DNA damage (40-60 mmol l 21 , in vitro) Rolf et al, 1999 31 No effects (800 mg vitamin E11000 mg vitamin C daily for 56 days, in vivo) Comhaire et al, 2000 41 Reduced ROS quantity; no effects on semen parameters (30 b-carotene1180 mg vitamin E daily for 3 months, in vivo) 38 Increased DNA damage after Percoll preparation (300-600 mmol l 21 vitamin C1 30-60 mmol l 21 vitamin E, in vitro) Verma and Kanwar, 1998 34 Preserved motility (800 mmol l 21 , in vitro) Donnelly et al, 1999 39,40 Reduced H 2 O 2 -induced ROS production and DNA damage (300-600 mmol l 21 , in vitro) Rolf et al, 1999 31 No effects (800 mg day 21 vitamin E11000 mg day 21 To be continued…”

Section: Antioxidant Studies Effectmentioning

confidence: 99%

See 2 more Smart Citations

The role of antioxidant therapy in the treatment of male infertility: an overview

Lombardo¹,

Sansone²,

Romanelli³

et al. 2011

Asian J Androl

100

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In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.

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Section: Vitamin Ementioning

confidence: 99%

Section: Vitamin Ementioning

confidence: 99%

Section: Antioxidant Studies Effectmentioning

confidence: 99%

See 1 more Smart Citation

The role of antioxidant therapy in the treatment of male infertility: an overview

Lombardo¹,

Sansone²,

Romanelli³

et al. 2011

Asian J Androl

100

View full text Add to dashboard Cite

show abstract

“…There was, however, no change in sperm motility or morphology. 20 Other studies did not show any significant effect on semen parameters using vitamin E as a single treatment 21,22 or in combination with other antioxidants.…”

Section: Vitamin E (Alpha-tocopherol)mentioning

confidence: 98%

Antioxidant therapy for male subfertility: myth or evidence-based?

Elmussareh

Mahrous

Kayes

2015

Trends Urology & Men Health

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The authors review the literature investigating the role of common dietary supplements that are being marketed as a remedy for male subfertility. They assess the evidence base supporting their use and their potential role in improving semen parameters alongside overall conception and live-birth rates. A round 15% of couples experience infertility, with up to 50% of these related to male factors. Oxidative stress caused by reactive oxygen species, including oxygen ions, free radicals and peroxides, has been reported to play a role in around half of all infertile men. These reactive oxygen species can, when present in high concentrations, damage the sperm membrane in addition to directly damaging the sperm DNA (Figure 1). MUHAMMAD ELMUSSAREH, AHMED MAHROUS AND OLIVER KAYES

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“…Efforts have been made to establish if sperm parameters could be improved by vitamin E supplementation [53]. Its seminal plasma concentration significantly increases when it is administered at doses of 300 and 1200mg/day for three weeks [54]. The -tocopherol concentration in spermatozoa is independent from the total α-tocopherol concentration in seminal plasma, and it significantly correlates with the percentage of motile spermatozoa [55].…”

Section: Vitamin Ementioning

confidence: 99%

Role of Antioxidants in the Treatment of Male Infertility

Gadallah¹

2018

SMOAJ

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Excretion of alpha-tocopherol into human seminal plasma after oral administration

Cited by 53 publications

References 17 publications

The role of antioxidant therapy in the treatment of male infertility: an overview

The role of antioxidant therapy in the treatment of male infertility: an overview

Antioxidant therapy for male subfertility: myth or evidence-based?

Role of Antioxidants in the Treatment of Male Infertility

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