Excretion of Epinephrine and Norepinephrine After Administration of Insulin and Methacholine*

Elmadjian, Fred; Lamson, Edwin T.; Freeman, Harry; Neri, R.; Varjabedian, Lois

doi:10.1210/jcem-16-7-876

Cited by 23 publications

(4 citation statements)

References 4 publications

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“…Abe (1924) estimates that less is required, usually over 0'5 and nearer 1 0pg/kg/min, to match the dilatation of the denervated pupil in the rabbit caused by apparently large doses of insulin. In man a urinary output of adrenaline like that caused by 0X1 u. insulin/kg requires an adrenaline infusion of the order of 0-15,ug/kg/min (Elmadjian, Lamson, Freeman, Neri & Varjabedian, 1956). Our own findings are more in accord with the last than with the earlier results.…”

Section: Discussionsupporting

confidence: 85%

Adrenaline release during insulin hypoglycaemia in the rabbit

Armin¹,

Grant²

1959

The Journal of Physiology

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Section: Discussionsupporting

confidence: 85%

Adrenaline release during insulin hypoglycaemia in the rabbit

Armin¹,

Grant²

1959

The Journal of Physiology

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“…Studies in adults have shown that only 0.5 to 2.0 per cent of the total amount of epinephrine infused intravenously is recoverable in the urine (15,16). Our studies indicate that parenterally administered epinephrine is recovered in the urine of newborn infants in a manner quantitatively similar to that in the adult.…”

Section: Discussionsupporting

confidence: 48%

The Excretion of Free Catecholamines by Newborn Infants*

Greenberg

Gardner

1960

The Journal of Clinical Endocrinology & Metabolism

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As an initial study of the role of catecholamines in neonatal adjustments, the excretion of free norepinephrine and epinephrine was determined in the urine of normal newborn infants, ranging in age from 5 to 233 hours at the start of the collection period. The 24-hour excretion of norepinephrine varied from 0.57 to 3.30 ng. and that of epinephrine varied from 0 to 0.77 ng. The percentage of norepinephrine, when related to total catecholamines, ranged between 70.8 and 100, except for 1 infant in whom no norepinephrine was recovered. An estimation was made of the ability of the newborn to metabolize parenterally injected epinephrine, by noting the percentage of a subcutaneously injected dose of epinephrine recovered in the ensuing twenty-four hours, using the mean excretion of epinephrine by normal controls as the baseline value. From 0 to 1.8 per cent of the injected dose of epinephrine was recovered in twenty-four hours, an amount quantitatively similar to that found in adults by other investigators. It would appear that chromaffin tissue in the newborn is capable of epinephrine synthesis and secretion. The role of nonchromaffin tissue in the excretion of norepinephrine in the newborn period presents an important area for further study, especially as regards states of altered maturation of the autonomic nervous system.

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“…6 Similarly, when arterenol was infused in identical manner, increasing amounts of the infused amine appeared in the urine with¬ out consistent changes in epinephrine excretion. On the other hand, when arterenol is infused, 3%-6% of the amine is recov¬ ered in the urine.…”

Section: Resultsmentioning

confidence: 89%

Methacholine Test and Epinephrine and Arterenol Excretion

Elmadjian¹,

Hope²,

Freeman³

1957

AMA Arch NeurPsych

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have published a prognostic test for the selection of neuropsychiatric patients for electric shock treatment. In essence, the test consists of administering 10 mg. of methacholine (Mecholyl) chloride intramuscularly and observing the systolic blood pressure for 25 minutes. In cases in which the systolic pressure was elevated two basic types of response were described: (A) that in which the systolic pressure failed to return to the preinjection level within the 25-minute period, and (B) that which showed a return to the control level during the observation period. Those subjects showing the first type of response were considered, by the authors, to have a significantly more favorable prognosis when subjected to EST than those showing the second type of response. The underlying physiological mechanism explaining these results was attributed to excess epinephrinelike secretion in the (A) type, while the (B) type was said to have an excess of arterenol-like secretion (Fig. 1). This explanation was based in part on the hemodynamic measurements obtained when nor¬ mal subjects were given methacholine dur-

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Excretion of Epinephrine and Norepinephrine After Administration of Insulin and Methacholine*

Cited by 23 publications

References 4 publications

Adrenaline release during insulin hypoglycaemia in the rabbit

Adrenaline release during insulin hypoglycaemia in the rabbit

The Excretion of Free Catecholamines by Newborn Infants*

Methacholine Test and Epinephrine and Arterenol Excretion

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