Excretion of Epinephrine and Norepinephrine in Various Emotional States*

Elmadjian, Fred; Hope, Justin M.; Lamson, Edwin T.

doi:10.1210/jcem-17-5-608

Cited by 167 publications

(52 citation statements)

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“…Swan 88 noted from his interviews with 60 subjects who received epinephrine by inh'avenous infusion that the effects were usually more marked than those experienced in previous situations of alarm, and concluded that epinephrine may well enter the circulation during stress, but at rates rather below 10 p,g per minute. These findings are in harmony with observations on the excretion in urine during stressful situations, as studied extensively by Elmadjian, Hope, and Lamson 24 and others. From the work of Elmadjian and his co-workers it also became clear that in certain conditions also norepinephrine is released in increased amounts, particularly in subjects who react in a more aggressive way.…”

Section: Physiology and Therapeutic Use Of Norepinephrine In Mansupporting

confidence: 91%

Epinephrine and norepinephrine actions and use in man

Euler

1960

Clin Pharma and Therapeutics

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Section: Physiology and Therapeutic Use Of Norepinephrine In Mansupporting

confidence: 91%

Epinephrine and norepinephrine actions and use in man

Euler

1960

Clin Pharma and Therapeutics

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“…[11], by means of emotional stimulation, and by Holmberg et at. [13], using tape-recorded industrial noise of 100 dB combined with intermittent light for 6 min.…”

Section: Discussionmentioning

confidence: 99%

Modifications of Epinephrine, Norepinephrine, Blood Lipid Fractions and the Cardiovascular System Produced by Noise in an Industrial Medium

Ortiz¹,

Argüelles²,

Crespin³

et al. 1974

Horm Res

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Catecholamine excretion, cholesterol, triglycerides, free fatty acids (FFA) and plasma 11-OH corticoids were measured in 18 normal workers of an aircraft factory exposed to turbine noise for 3 h. Blood pressure and pulse frequency were also registered. In 72% of the subjects, marked elevations of catecholamine excretion were found, correlating fairly well with increases of cholesterol, FFA, blood pressure and pulse frequency. Surprisingly, after 3 h of noise exposure, the plasma 11-OH corticoid mean value was slightly lower than the one of the early morning in resting conditions; this could be ascribed to the pronounced midday drop of plasma corticoids, characteristic of the circadian cortisol variation. This could counteract the moderate corticoadrenal stimulation caused by the noise stress. The blood pressure and plasma lipid elevation found in these workers might be detrimental to personnel suffering from atherosclerosis or other vascular pathology.

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“…Euler and Lundberg [ 19] found that epineph rine excretion was greater on days when pi lots flew than on nonflying days. Elmadjian et al [ 17] studied urinary excretion of CAs in psychiatric patients and their therapists dur ing interviews. Active, aggressive emotional displays were related to increased norepi nephrine excretion.…”

Section: Urinary Excretion O F Catecholaminesmentioning

confidence: 99%

Avenues of Investigation for the Role of Catecholamines in Anxiety

Kopin¹

1984

Psychopathology

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Many of the cardinal somatic symptoms associated with anxiety states are produced by the sympathoadrenal medullary discharge of catecholamines (CA) described over 50 years ago as ‘fight or flight’ responses. During the last decade, development of sensitive convenient assays for CA and their metabolites in tissues, cerebrospinal fluid, plasma and urine has made possible assessment of brain and peripheral adrenergic activity during stress, in neuropsychiatric disorders, and after administration of drugs. Studies in animal models of stress and anxiety parallel studies in humans. In rats, there are genetic differences in the graded adrenergic alerting responses to administered or anticipated stress, analogous to trait anxiety in humans. Behavioral responses to stress may be attenuated in rats by pharmacological blockade of peripheral CA release, suggesting a positive feedback process in which released CA augment behavioral responses, possibly analogous to use of clonidine or β-adrenergic blocking agents to diminish somatic symptoms attending anxiety-provoking situations in humans. The biochemical evaluation of adrenergic responses by examination of CA and their metabolites in body fluids of humans with various levels of sympathetic activation will be discussed.

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Excretion of Epinephrine and Norepinephrine in Various Emotional States*

Cited by 167 publications

References 0 publications

Epinephrine and norepinephrine actions and use in man

Epinephrine and norepinephrine actions and use in man

Modifications of Epinephrine, Norepinephrine, Blood Lipid Fractions and the Cardiovascular System Produced by Noise in an Industrial Medium

Avenues of Investigation for the Role of Catecholamines in Anxiety

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