Excretion of oxytetracycline in eggs after medication of laying hens

Abstract

The kinetics of oxytetracycline elimination into eggs were determined separately for albumen and yolk after oral administration through either drinking water (0.1-0.25 and 0.5 g/l for 5 days) or feed (300 and 600 ppm for 7 days) or after intramuscular injections (3 X 15 mg/kg body weight and 3 X 30 mg/kg body weight), 24 hours apart. Residues were assayed by a microbiological agar diffusion method, with Bacillus cereus as test-organism. The detection threshold was 0.07 micrograms/g for albumen and 0.2 micrograms/g for yolk. In all cases, the elimination period lasted longer for the yolk; it varied between 0 and 10 days after treatment was discontinued, according to administration routes and dosages. The conditions of oxytetracycline utilization in laying hens are discussed. The oral route only might be used to adhere to the proposals presented by the Joint FAO/WHO Expert Committee on Food Additives.

Residues of doxycycline and oxytetracycline in eggs after medication via drinking water to laying hens

“…Frieser etal. (1986) and Roudaut et al (1987Roudaut et al ( , 1989 also found similar observations after medication via the drinking water and feed. All of these tetracyclines seem to persist longer in yolk (Nogawa et al 1981, Roudaut et al 1989.…”

“…The present experiment, however, showed that mean peak concentration of OTC in the yolk, reached 2 days after withdrawal, was approximately double that reported by Nogawa et al (1981). As with the depletion period, Nogawa et al (1981) and Roudaut et al (1987) noted that OTC was detected in the yolk for 4 days after withdrawal, a much shorter period than in the present experiment. The depletion period in the albumin also lasted longer in the present experiment than in others (Nogawa et al 1981, Roudaut et al 1987).…”

“…According to them, the mean peak concentration of OTC in the yolk was 0-77 /*g/g, which occurred 2 days after withdrawal. Roudaut et al (1987) also noted a similar increase in the concentration of OTC in yolk during medication of 0-5 g/1 for 5 days. The present experiment, however, showed that mean peak concentration of OTC in the yolk, reached 2 days after withdrawal, was approximately double that reported by Nogawa et al (1981).…”

Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline

“…Analytical procedures suggested in the literature for OXY detection and quantification regard microbiological methods (Jevinova et al, 2003;Gesche et al, 2001;Piriz et al, 2001;Myllyniemi et al, 2000;Okerman et al, 2001;Tantillo et al, 1997;Markakis, 1996;Wanner et al, 1994;Hasselberger, 1993;Jinbo et al, 1992;Roudaut et al, 1987;Muellerbrennecke et al, 1980) or liquid-chromatographic techniques (Khosrokhavar et al, 2008;Fletouris and Papapanagiotou, 2008;Maia et al, 2008;Kowalski and Pomorska, 2007;Biswas et al, 2007;Fritz and Zuo, 2007;Miller et al, 2007;Kowalski et al, 2006;Hosseini et al, 2006;Poapolathep et al, 2008;Yegorova et al, 2006;Pena et al, 2005;Rupp and Anderson, 2005;Lu et al, 2004;Schneider et al, 2007;Kim et al, 2006). The former is unsuitable for routine control procedures considering that each trial may take several days, and analytical laboratories also require proper facilities to handle biological compounds safely.…”

Depletion of colistin in eggs following medication of laying hens

“…Little is known concerning colistin elimination in chicken eggs (6). Therefore, this study, which is part of experiments performed at the National Laboratory of Veterinary Drugs concerning antibiotic deposition in eggs (3,4,5), was undertaken to determine to what extent eggs were contaminated by colistin after oral and parenteral administration.…”