Excretion of various porphyrins and their corresponding porphyrinogens by rabbits after intravenous injection

Sano, Seiyo; Rimington, C.

doi:10.1042/bj0860203

Cited by 21 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Holeiek (4) has ascertained that 97% of coproporphyrin is excreted in the form of coproporphyrinogen during lead poisoning. Sano &Rimington (5) have shown that coproporphyrinogen, and not coproporphyrin, is . excreted by the kidneys.…”

Section: Introductionmentioning

confidence: 98%

Porphyrinogens in Urine in Various Types of Porphyrias

Martásek¹,

Jirsa²,

Kordač³

1982

CCLM

View full text Add to dashboard Cite

Porphyrinogens were determined in very fresh, diluted morning urine in two types of hepatic porphyria, using a simple and very quick spectrophotometric method. It was shown that acidification by itself is insufficient for the complete conversion of colourless porphyrinogens into porphyrins in photometric determination of porphyrins in diluted urine. A correlation was shown between percentual content of porphyrinogens and the sum of pentacarboxyporphyrin and coproporphyrin. A difference was found between the excretion of porphyrinogens in morning fresh urine in porphyria cutanea tarda (average porphyrinogen fraction 22.5%, SD 10.3% of total porphyrins) and in acute intermittent porphyria (average porphyrinogen fraction 77.1 %, SD 9.3% of total porphyrins). The method is at the same time suitable for the detection of urobilinoids in urine. Oxidation of the urine in acute intermittent porphyria is recommended before adsorption on talc and subsequent thin j layer chromatography, because porphyrinogens are not adsorbed on talc.

show abstract

Section: Introductionmentioning

confidence: 98%

Porphyrinogens in Urine in Various Types of Porphyrias

Martásek¹,

Jirsa²,

Kordač³

1982

CCLM

View full text Add to dashboard Cite

show abstract

“…The higher relative porphyrinogen content in normal subjects may be due to their predominant coproporphyrin excretion (76.7 %) since this tetracarboxylporphyrin is mostly excreted by urine as porphyrinogen (Sano and Rimington 1963;Kalivas 1969). The mean percentual coproporphyrin fraction in our PCT and AIP patients was 20.0% and 46.5 %, respectively.…”

Section: Resultsmentioning

confidence: 99%

Urinary Porphyrinogens in Normal Subjects and in Patients with Porphyria Cutanea Tarda and Acute Intermittent Porphyria

Hernández

Sepulveda²,

Fernandez-Cuartero³

et al. 1993

Horm Metab Res

View full text Add to dashboard Cite

“…The discovery that porphyrins preferentially localize and fluoresce in tumour tissue, the purification of HpD from crude hematoporphyrin [33][34][35][36][37] and the fact that it could be activated by red light led to the first trials using HpD as a PS by Thomas Dougherty's group in the 1970s. Exciting results were obtained in the treatment of cutaneous and subcutaneous malignant tumours with tumour regression being observed in 111 cases.…”

Section: History Of Pdtmentioning

confidence: 99%

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing. At present, PDT is mainly used in the treatment of wet age-related macular degeneration, for precancerous conditions of the skin (e.g. actinic keratosis) and in the palliative care of advanced cancers, for instance of the bladder or the oesophagus. Due to a lack of phase III clinical trials and limitations of light penetration to deeper lying tumours (in excess of 1 cm), PDT is still not used as a first line cancer treatment, which is surprising given the first clinical trials by Dougherty's group dating back to the 1970's. However research continues to demonstrate the potential benefits of PDT and the need to stimulate funding and uptake of clinical studies using next generation photosensitizers offering advanced targeted delivery, improved photodynamic dose combined with modern light delivery technologies. This review surveys the available PDT treatments and emerging novel developments in the field with a particular focus on two-photon techniques that are anticipated to improve the effectiveness of PDT in tissues at depth and on next generation drugs that work without the need of the presence of oxygen for photosensitization making them effective where hypoxia has taken hold.

show abstract

Excretion of various porphyrins and their corresponding porphyrinogens by rabbits after intravenous injection

Cited by 21 publications

References 11 publications

Porphyrinogens in Urine in Various Types of Porphyrias

Porphyrinogens in Urine in Various Types of Porphyrias

Urinary Porphyrinogens in Normal Subjects and in Patients with Porphyria Cutanea Tarda and Acute Intermittent Porphyria

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Contact Info

Product

Resources

About