Executive Cognitive Dysfunction Without Stroke After Long-Term Mechanical Circulatory Support

Komoda, Takeshi; Drews, Thorsten; Sakuraba, S; Kubo, Masami; Hetzer, Roland

doi:10.1097/00002480-200403000-00027

Cited by 4 publications

(8 citation statements)

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“…While patients bridged to transplantation with a VAD have similar post-transplant physical recovery and emotional well-being as patients who never required VAD support, they may have poorer residual cognitive functioning post-transplant [48, 49]. Cognitive impairments may in part be due to the higher risk of thromboembolism while supported on a VAD.…”

Section: Pre-transplant Organ Specific Cognitive Disorders and Encmentioning

confidence: 99%

“…silent infarctions) on cognitive functioning is speculated to be significant over time. Although it is not feasible to repeatedly perform computed tomography of the brain, transcranial Doppler may be beneficial for predicting the risk and periodic neuropsychologic or cognitive testing may identify silent cerebral infarctions [49]. …”

Section: Pre-transplant Organ Specific Cognitive Disorders and Encmentioning

confidence: 99%

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Psychiatric Aspects of Organ Transplantation in Critical Care

DiMartini

Crone

Fireman

et al. 2008

Critical Care Clinics

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Section: Pre-transplant Organ Specific Cognitive Disorders and Encmentioning

confidence: 99%

Section: Pre-transplant Organ Specific Cognitive Disorders and Encmentioning

confidence: 99%

Psychiatric Aspects of Organ Transplantation in Critical Care

DiMartini

Crone

Fireman

et al. 2008

Critical Care Clinics

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“…Furthermore, at least two recent reports question the impact of lower doses of CRT and chemotherapy on neurocognitive functions. 33, 34 Neurocognitive dysfunction has also been consistently reported in samples of adults with epilepsy,35-39 stroke,40-42 and cerebrovascular abnormalities 43-45. Increased incidence of such neurologic disorders has been documented in survivors of childhood cancer treated with cranial radiation 46, 47.…”

Section: Methodsmentioning

confidence: 95%

“… Note: Kappa coefficients ≥ .20 indicate at least fair agreement between dichotomous variables 42, 43 *

all p values < .0001 given large sample sizes.

…”

Section: Tablesmentioning

confidence: 99%

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Reliability and validity of the Childhood Cancer Survivor Study Neurocognitive Questionnaire

Krull

Gioia

Ness

et al. 2008

Cancer

105

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BACKGROUND. Up to 40% of childhood cancer survivors may experience neurocognitive impairment in 1 or more specific domains. As such, regular monitoring has been recommended for patients exposed to cranial irradiation and/or antimetabolite chemotherapy. This study reports the results of a questionnaire developed to identify those survivors who may be experiencing neurocognitive problems. METHODS. Participants for this study were 7121 members of the Childhood Cancer Survivor Study cohort (6739 survivors and 382 siblings). These participants completed a new neurocognitive questionnaire designed to assess functions commonly affected by cancer therapy, as well as a standard measure of emotional functioning. A measure of cognitive and emotional functioning was also completed on a subset of the patients roughly 7 years before the current questionnaire. Responses to the questionnaires among subgroups of survivors were then analyzed to examine the reliability and validity of the new neurocognitive questionnaire. RESULTS. Four reliable factors were identified that assessed task efficiency, emotional regulation, organization, and memory skills. These neurocognitive factors accurately discriminated survivors who were at “high risk” for neurocognitive dysfunction, because of neurologic abnormalities or a history of intensive focal cranial irradiation, from healthy “low‐risk” survivors and siblings. CONCLUSIONS. The questionnaire demonstrated excellent reliability, as well as construct and discriminative validity. It appears to be a practical and efficient tool for monitoring neurocognitive outcomes in adult survivors of pediatric cancer. Cancer 2008. © 2008 American Cancer Society.

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Outcome of pediatric heart transplantation recipients treated with ventricular assist device

Jahnukainen

Rautiainen

Mattila

et al. 2012

Pediatric Transplantation

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This study was conducted to evaluate the long-term prognosis of pediatric HTx patients treated with VAD before transplantation. The clinical data of six patients bridged to HTx with Berlin Heart EXCOR pediatric device were analyzed retrospectively. Information about graft function, CA results, and EMB findings as well as appearance DSA was collected. Also, information about growth and cognitive function was analyzed. These findings were compared with age-, gender-, and diagnosis-matched HTx patients. During the median follow-up time of four and half yr after HTx, the prognosis including graft function, number of rejection episodes, and incidence of coronary artery vasculopathy, growth and cognitive development did not differ between VAD-bridged HTx patients compared with control patients. In both groups, one patient developed positive DSA titer after HTx. Our single-center experience suggests that the prognosis of pediatric HTx patients treated with VAD before transplantation is not inferior to that of other HTx patients.

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Executive Cognitive Dysfunction Without Stroke After Long-Term Mechanical Circulatory Support

Cited by 4 publications

References 0 publications

Psychiatric Aspects of Organ Transplantation in Critical Care

Psychiatric Aspects of Organ Transplantation in Critical Care

Reliability and validity of the Childhood Cancer Survivor Study Neurocognitive Questionnaire

Outcome of pediatric heart transplantation recipients treated with ventricular assist device

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