Executive Function, Working Memory, and Medication Adherence Among Older Adults

Insel, Kathleen C.; Morrow, Daniel G.; Brewer, Barbara B.; Figueredo, Aurelio J.

doi:10.1093/geronb/61.2.p102

Cited by 301 publications

(281 citation statements)

References 35 publications

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“…However, other studies stated that older patients are at increased risk of non-adherence due to age related factors such as workingmemory loss and impaired executive performance, in addition to their administering multiple medications. [29,23] In the current study, there was a statistically significant association between the educational level and the medication non-adherence. Higher percentage (79.6%) of non-adherence patients had only primary and/or secondary education.…”

Section: Discussionsupporting

confidence: 44%

Prevalence and Risk Factors of Non-Adherence in Psychiatric Patients in Taif, Saudi Arabia

Alalyani¹

2017

WJPR

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Objectives: To estimate the prevalence of non-adherence to medication among and to explore the different reasons for drug non adherence among patient in mental health hospital in Taif city. Subjects and methods:It is a Cross-sectional descriptive study. The study included 255 patients who were following in Mental HealthHospital clinic. The total number was 255 patients, 233 patients were included in the study and 22 were excluded from the study according to eligibility criteria. The tool of the study was a self-administered questionnaire, which consists of three Parts: Demographic data, psychiatric diagnosis and reasons of not take the treatment. Result:Incidence of non-adherence was high (84.1%). The factors that increased the likelihood of non-adherence were absence of job, familial support and health education about medication use in addition to occurrence of side effects. Conclusion: The frequency of non-adherence is relatively high among the patients with psychiatric disorders in Taif city. Prevention strategies should focus on enhancing socioeconomic status (education and employment) and effective health education of patients to enable them to deal with adverse drug effects.

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Section: Discussionsupporting

confidence: 44%

Prevalence and Risk Factors of Non-Adherence in Psychiatric Patients in Taif, Saudi Arabia

Alalyani¹

2017

WJPR

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“…Indeed, lower neurocognitive function has been associated with nearly four times greater risk of medication noncompliance in older adults (29). Our finding that executive functioning, as measured by Trail Making Test part B, worsened after transplant may have important implications for patient management because executive functioning is predictive of self-management and objectively measured adherence among older adults (34). Indeed, previous studies among primary care patients have demonstrated that better executive function is associated with more than a 3-fold greater likelihood of medication adherence after adjustment for background ORIGINAL RESEARCH characteristics (35), and we have previously shown that poorer executive functioning before lung transplantation is associated with greater mortality after transplant (21).…”

Section: Discussionmentioning

confidence: 85%

Neurocognitive Changes after Lung Transplantation

Smith¹,

Rivelli²,

Waters³

et al. 2014

Annals ATS

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“…Once we controlled for baseline level of function (including executive function) as well as other variables including years of education, the difference in adherence between African-American and white subjects was no longer significant. Optimal adherence depends on patients taking the prescribed medication at the right time and in the correct manner [55]. Beyond working memory and encoding and storage of information, the organization and planning needed for medication adherence requires intact executive function.…”

Section: Discussionmentioning

confidence: 99%

Racial Differences in Adherence to Antidepressant Treatment in Later Life

Kales

Nease

Sirey

et al. 2013

The American Journal of Geriatric Psychiatry

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Objective Although antidepressants are an effective treatment for later-life depression, older patients often choose not to initiate or to discontinue medication treatment prematurely. While racial differences in depression treatment preferences have been reported, little is known about racial differences in antidepressant medication adherence among older patients. Design Prospective, observational study comparing antidepressant adherence for older African-American and white primary care patients. Participants One hundred and eighty-eight subjects aged 60 and older, diagnosed with clinically significant depression with a new recommendation for antidepressant treatment by their primary care physician. Measurement Study participants were assessed at study entry and at four-month follow-up (encompassing the acute treatment phase). Depression medication adherence was based on a well-validated self-report measure. Results At four-month follow-up, 61.2% of subjects reported that they were adherent to their antidepressant medication. In unadjusted and two of the three adjusted analyses, African-American subjects (n=82) had significantly lower rates of four-month antidepressant adherence than white subjects (n=106). African-American females had the lowest adherence rates (44.4%) followed by African-American males (56.8%), white males (65.3%) and white females (73.7%). In logistic regression models controlling for demographic, illness, and functional status variables, significant differences persisted between African-American women and white women in reported four-month antidepressant adherence (OR 3.58, 95% CI 1.27-10.07, Wald Chi-square =2.42, df=1, p<0.02). Conclusions The results demonstrate racial and gender differences in antidepressant adherence in older adults. Depression treatment interventions for the older adults should take into account the potential impact of race and gender on adherence to prescribed medications.

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Executive Function, Working Memory, and Medication Adherence Among Older Adults

Cited by 301 publications

References 35 publications

Prevalence and Risk Factors of Non-Adherence in Psychiatric Patients in Taif, Saudi Arabia

Prevalence and Risk Factors of Non-Adherence in Psychiatric Patients in Taif, Saudi Arabia

Neurocognitive Changes after Lung Transplantation

Racial Differences in Adherence to Antidepressant Treatment in Later Life

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