Exenatide suppresses 1,2-dimethylhydrazine-induced colon cancer in diabetic mice: Effect on tumor angiogenesis and cell proliferation

Tawfik, Mona K.; Mohamed, Magda I.

doi:10.1016/j.biopha.2016.05.005

Cited by 18 publications

(21 citation statements)

References 52 publications

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“…In agreement with us, one study tested 5FU PLGA nanoparticles at pH = 7.4 not in an acidic pH [27]. [5,28] for induction of colonic dysplasia. Indeed, the main route of administration of Di-MH is the subcutaneous route [4,29].…”

Section: In Vitro Drug Release Of Mixed 5fu-plnssupporting

confidence: 66%

“…1,2-dimethylhydrazine (Di-MH) was supplied by Sigma-Aldrich (St. Louis, MO, USA) and diluted with sterile saline. Mice received weekly doses of Di-MH (20 mg/kg) by subcutaneous (s.c.) injections for 16 weeks [ 5 , 28 ] for induction of colonic dysplasia. Indeed, the main route of administration of Di-MH is the subcutaneous route [ 4 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…Several animal models of colon cancer have been developed in order to explore its molecular pathogenesis and to investigate the role of various potential preventive nutritional and pharmacologic agents [ 3 ]. Among the various chemically prompted animal models of dysplastic colon, the 1,2-dimethylhydrazine (Di-MH) model is universally utilized [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis

et al. 2021

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The use of 5-fluorouracil (5FU) is associated with multifaceted challenges and poor pharmacokinetics. Poly(lactic-co-glycolic acid)-lipid hybrid nanoparticles (PLNs)-based therapy has received attention as efficient carriers for a diversity of drugs. This study evaluated the in vivo chemotherapeutic and anti-proliferative efficacy of 5FU-loaded PLNs against 1,2-dimethylhydrazine (Di-MH) prompted colon dysplasia in mice compared to free 5FU. 5FU PLNs were prepared. Male Swiss albino mice were distributed to six experimental groups. Group 1: Saline group. All the other groups were injected weekly with Di-MH [20 mg/kg, s.c.]. Group 2: Di-MH induced colon dysplasia control group. Groups 3 and 4: Di-MH + free 5FU treated group [2.5 and 5 mg/kg]. Groups 5 and 6: Di-MH + 5FU-PLNs treated group [2.5 and 5 mg/kg]. Free 5FU and 5FU-PLNs doses were administered orally, twice weekly. Treatment with 5FU-PLNs induced a higher cytoprotective effect compared to free 5FU as indicated by lower mucosal histopathologic score and reduction in number of Ki-67 immunpositive proliferating nuclei. Additionally, there was significant upregulation of p53 and caspase 3 genes in colon specimens. Our results support the validity of utilizing the PLNs technique to improve the chemopreventive action of 5FU in treating colon cancer.

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Section: In Vitro Drug Release Of Mixed 5fu-plnssupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis

et al. 2021

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“…Antimutagenicity results also stimulate the anticarcinogenicity evaluation since there is a direct correlation between mutagenesis and carcinogenesis (Ribeiro, 2003), and thus, establishes a relationship between antimutagenesis and anticarcinogenesis. The biomarker chosen for indirect evaluation of anticarcinogenesis was the ACF induced by DMH (Tawfik and Mohamed, 2016). Based on this context Activia ® can be indicated as an anticancer product since it reduced the incidence of aberrant crypt foci around 70 to 80%.…”

Section: Discussionmentioning

confidence: 99%

Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

et al. 2017

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ABSTRACT. Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia ® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa.

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“…This suggests a serious issue of environmental contamination. The compound is currently used in many cancer studies [44,45] because it is a known carcinogen that can cause sporadic forms of colon carcinoma in rats resulting in a reproducible experimental models for pre-clinical screening of test compounds based on its metabolism [46]. It has been reported that the metabolism of dimethyl hydrazine leads to the formation of azoxymethane methylazoxymethanol and methyl diazonium ions, which can cause alkylation of the DNA in the colon mucosa [47].…”

Section: Dimethylhydrazinementioning

confidence: 99%

Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards

Nwaiwu

Itumoh²

2017

Beverages

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Recent analysis of palm wine, a traditional drink fermented mainly by yeasts, revealed the presence of several chemicals that were not products of yeast fermentation. The chemicals included styrene, benzene, trimethyldioxolane, dichloromethane, methylene fluoride, dichloroethanol, benzylisoquinoline and tetraacetyl-D-xylonic nitrile. A review of the concentrations of these compounds in palm wine found that the benzene concentrations in all samples reviewed ranged from 56-343 ppm and were within permissible limits, whereas the styrene values (1505-5614 ppm) in all the palm wine samples evaluated were well over the recommended concentration that is immediately dangerous to life or health. Other chemical compounds evaluated varied according to location or sample source. The concentrations obtained are estimates only and a quantitative study needs to be carried out before the impact of these chemicals on health is evaluated. A search on The PubChem Project, the open chemical database, showed the description, properties and uses of these chemicals. Further searches carried out within other databases like PubMed, Scopus and Google Scholar, using each chemical's name as a search term, showed possible hazards and adverse health conditions caused by these chemicals, especially styrene, benzene and dichloromethane. The point at which the chemicals are introduced into the drink is still not clear and requires further investigation. The chemicals can be hazardous to humans and there is need to establish and maintain a system that can guarantee permissible levels in the drink. This can be carried out using concentrations of the chemicals that are already known to be immediately dangerous to life or health as a reference point.

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Exenatide suppresses 1,2-dimethylhydrazine-induced colon cancer in diabetic mice: Effect on tumor angiogenesis and cell proliferation

Cited by 18 publications

References 52 publications

Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis

Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis

Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards

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