Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride

Fu, Rong; Niu, Ruiyan; Zhao, Fei; Wang, Jixiang; Cao, Qiqi; Yu, Yanghuan; Liu, Ci; Zhang, Ding; Sun, Zilong

doi:10.1016/j.chemosphere.2021.132658

Cited by 17 publications

(2 citation statements)

References 48 publications

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“…Conversely, exercise has been indicated to produce numerous beneficial effect on gut health, for example by increasing gut microbiota diversity (Mitchell et al, 2019;Xu et al, 2022) and SCFA production (Barton et al, 2018), and it has been demonstrated that 3-6 months of treadmill exercise attenuated HFD-induced as well as toxin exposure-induced gut microbiota dysbiosis in adolescent male mice (Wang et al, 2022;Fu et al, 2022). Notably, a voluntary exercise-induced increase in AHN was attenuated when gut microbiota were depleted using chronic administration of antibiotics (Nicolas et al, 2024), suggesting a role for the gut microbiota in the pro-neurogenic effects of exercise.…”

Section: Introductionmentioning

confidence: 99%

A cafeteria diet blunts effects of exercise on adult hippocampal neurogenesis but not neurogenesis-dependent behaviours in adult male rats

Nota,

Dohm-Hansen,

Nicolas

et al. 2024

Preprint

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Animal studies have shown that a cafeteria (CAF) diet (high in saturated fat and sugar), is associated with memory impairments and increased anxiety, while exercise can enhance antidepressant-like effects and cognitive function. The mechanisms underlying the effects of a CAF diet, exercise, or their convergence on memory, mood and anxiety are not fully understood, but alterations in adult hippocampal neurogenesis (AHN), gut microbial metabolites, or plasma metabolic hormones may play a role. Therefore, this study investigated whether a 7.5-week voluntary running exercise intervention in young adult male rats could alter the effects of a concurrent CAF diet on depression-like, anxiety-like and cognitive behaviours and AHN, and determined associated changes in metabolic hormones and gut microbial metabolites. We found that exercise produced a mild anxiolytic effect, regardless of diet, and increased PYY, a hormone previously shown to reduce anxiety-like behaviour. CAF diet induced differential abundance of caecal metabolites, and exercise attenuated CAF diet-induced decreases in certain metabolites implicated in cognitive function or depression-like behaviour. Although exercise exerted antidepressant-like effects in the FST, induced subtle improvements in spatial learning strategy, and increased plasma metabolic hormones previously implicated in depression-like behaviour in CAF diet-fed animals, CAF diet blunted exercise-induced increases in plasma GLP-1 and AHN, suggesting that exercise should be accompanied by a healthy diet to increase AHN. Together, these findings highlight the importance of exercise and healthy diet for hippocampal health and provide insight into potential metabolite and hormone-mediated mechanisms underlying the effects of CAF diet and exercise on brain and behaviour.Key points- Diets high in saturated fat and sugar are associated with memory impairments and increased anxiety while exercise can exert antidepressant-like effects and enhance cognitive function, but the biological underpinnings of these effects and whether exercise can negate effects of such diets remain to be elucidated.- We found that running exercise modestly reduced anxiety in rats fed either a healthy or a cafeteria-style diet and increased a hormone (peptide YY) previously shown to decrease anxiety.- Running exercise exerted antidepressant-like effects in cafeteria diet-fed rats and attenuated cafeteria diet-induced decreases in gut metabolites previously implicated in cognition or depression-like behaviour.- Cafeteria diet blunted exercise-induced production of new neurons in the hippocampus, a brain region important in mood and memory.- These data highlight the importance of combining exercise with a healthy diet for hippocampal health, while identifying potential targets for intervention or dietary supplementation to prevent a cafeteria diet blunting beneficial effects of exercise

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Section: Introductionmentioning

confidence: 99%

A cafeteria diet blunts effects of exercise on adult hippocampal neurogenesis but not neurogenesis-dependent behaviours in adult male rats

Nota,

Dohm-Hansen,

Nicolas

et al. 2024

Preprint

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“…Even though F - is beneficial for physiological functions, its excess leads to dental and skeletal fluorosis and damage of various tissues, organs, and systems ( 12 , 13 , 14 , 15 , 16 , 17 , 18 ). Its toxicity mechanisms are complex, as they interact with enzymes, induce inflammation, and damage cells ( 19 , 20 ).…”

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confidence: 99%

Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects

Radovanović

Antonijević

Baralić

et al. 2022

Archives of Industrial Hygiene and Toxicology

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This study aimed to investigate the effect of 150 mg/L sodium fluoride (NaF) on redox status parameters and essential metals [copper (Cu), iron (Fe), and zinc (Zn)] in the blood, liver, kidney, brain, and spleen of Wistar rats and to determine the protective potential of selenium (Se) against fluoride (F-) toxicity. Male Wistar rats were randomly distributed in groups of five (n=5) receiving tap water (control) or water with NaF 150 mg/L, NaF 150 mg/L + Se 1.5 mg/L, and Se 1.5 mg/L solutions ad libitum for 28 days. Fluorides caused an imbalance in the redox and biometal (Cu, Fe, and Zn) status, leading to high superoxide anion (O2 .-) and malondialdehyde (MDA) levels in the blood and brain and a drop in superoxide dismutase (SOD1) activity in the liver and its increase in the brain and kidneys. Se given with NaF improved MDA, SOD1, and O2 .- in the blood, brain, and kidneys, while alone it decreased SH group levels in the liver and kidney. Biometals both reduced and increased F- toxicity. Further research is needed before Se should be considered as a promising strategy for mitigating F- toxicity.

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Fluoride in Groundwaters of Southeastern Algeria Region and Their Removal by Cattle Bone Particles

Assami

Messaïtfa

2023

Water Air Soil Pollut

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Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride

Cited by 17 publications

References 48 publications

A cafeteria diet blunts effects of exercise on adult hippocampal neurogenesis but not neurogenesis-dependent behaviours in adult male rats

A cafeteria diet blunts effects of exercise on adult hippocampal neurogenesis but not neurogenesis-dependent behaviours in adult male rats

Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects

Fluoride in Groundwaters of Southeastern Algeria Region and Their Removal by Cattle Bone Particles

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