Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Jia, Dandan; Zhang, Huijie; Liu, Tiemin; Wang, Ru

doi:10.3390/metabo14030135

Cited by 2 publications

(2 citation statements)

References 153 publications

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“…Mitochondrial homeostasis in BAT plays a pivotal role in the thermoregulatory and metabolic processes. Voluntary physical exercise promotes thermogenesis, insulin sensitivity, mitochondrial activity, and biogenesis in BAT [70][71][72]. CL is a key effector of brown/beige adipocytes' thermogenic programs and is linked to mitochondrial biogenesis and function in response to regular exercise [15].…”

Section: Exercise Modulates Brown Adipose Tissuementioning

confidence: 99%

The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat

Shao,

Zhang,

Jia

2024

Metabolites

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There is a notable correlation between mitochondrial homeostasis and metabolic disruption. In this review, we report that obesity-induced disruption of mitochondrial homeostasis adversely affects lipid metabolism, adipocyte differentiation, oxidative capacity, inflammation, insulin sensitivity, and thermogenesis in thermogenic fat. Elevating mitochondrial homeostasis in thermogenic fat emerges as a promising avenue for developing treatments for metabolic diseases, including enhanced mitochondrial function, mitophagy, mitochondrial uncoupling, and mitochondrial biogenesis. The exerkines (e.g., myokines, adipokines, batokines) released during exercise have the potential to ameliorate mitochondrial homeostasis, improve glucose and lipid metabolism, and stimulate fat browning and thermogenesis as a defense against obesity-associated metabolic diseases. This comprehensive review focuses on the manifold benefits of exercise-induced exerkines, particularly emphasizing their influence on mitochondrial homeostasis and fat thermogenesis in the context of metabolic disorders associated with obesity.

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Section: Exercise Modulates Brown Adipose Tissuementioning

confidence: 99%

The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat

Shao,

Zhang,

Jia

2024

Metabolites

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“…These interactions are complex and contribute to the multisystem nature of metabolic disorders. For a detailed exploration of the systemic effects of AT and its implications for cardiovascular, musculoskeletal, and renal health in the context of MASLD/MASH, readers are encouraged to consult the following comprehensive reviews ( Chow et al, 2022 ; Gilani et al, 2024 ; Hafiane, 2024 ; Jia et al, 2024 ). Therefore, this manuscript prioritizes the heart, muscles, and kidneys due to their critical interplay with metabolic health and their direct connection to the primary complications associated with MASH, thereby offering clearer targets for therapeutic intervention and management strategies.…”

Section: Introductionmentioning

confidence: 99%

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

Sandireddy,

Sakthivel,

Gupta

et al. 2024

Front. Cell Dev. Biol.

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Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the most common liver disorder worldwide, with an estimated global prevalence of more than 31%. Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), is a progressive form of MASLD characterized by hepatic steatosis, inflammation, and fibrosis. This review aims to provide a comprehensive analysis of the extrahepatic manifestations of MASH, focusing on chronic diseases related to the cardiovascular, muscular, and renal systems. A systematic review of published studies and literature was conducted to summarize the findings related to the systemic impacts of MASLD and MASH. The review focused on the association of MASLD and MASH with metabolic comorbidities, cardiovascular mortality, sarcopenia, and chronic kidney disease. Mechanistic insights into the concept of lipotoxic inflammatory “spill over” from the MASH-affected liver were also explored. MASLD and MASH are highly associated (50%–80%) with other metabolic comorbidities such as impaired insulin response, type 2 diabetes, dyslipidemia, hypertriglyceridemia, and hypertension. Furthermore, more than 90% of obese patients with type 2 diabetes have MASH. Data suggest that in middle-aged individuals (especially those aged 45–54), MASLD is an independent risk factor for cardiovascular mortality, sarcopenia, and chronic kidney disease. The concept of lipotoxic inflammatory “spill over” from the MASH-affected liver plays a crucial role in mediating the systemic pathological effects observed. Understanding the multifaceted impact of MASH on the heart, muscle, and kidney is crucial for early detection and risk stratification. This knowledge is also timely for implementing comprehensive disease management strategies addressing multi-organ involvement in MASH pathogenesis.

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Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Cited by 2 publications

References 153 publications

The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat

The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

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