Exercise &amp; Sports Science Australia (ESSA) position statement on exercise and chronic kidney disease

Smart, Neil A.; Williams, Andrew D.; Levinger, Itamar; Selig, Steve E; Howden, Erin J.; Coombes, Jeff S.; Fassett, Robert G.

doi:10.1016/j.jsams.2013.01.005

Cited by 132 publications

(171 citation statements)

References 44 publications

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“…Nevertheless, a recent review notes a scarcity of data describing the effects of exercise training on plasma albumin in models of CKD [40]. Furthermore, data describing the effects of HIIT on plasma albumin in models of CKD is particularly rare.…”

Section: Ckd) Is Timelymentioning

confidence: 99%

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

Tucker

Briskey

Scanlan

et al. 2015

Free Radical Biology and Medicine

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Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO 2 max), versus low intensity exercise (45-50% VO 2 max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation.Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (p<0.001). Compared to low intensity exercise, high intensity interval training resulted in increased mRNA expression of Cat (p<0.001) and Tnfrsf1b (p=0.047). In this study, high intensity interval training was superior to sedentary behaviour and low intensity exercise as high intensity interval training beneficially influenced expression of genes related to endogenous antioxidant enzyme activity and inflammation.

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Section: Ckd) Is Timelymentioning

confidence: 99%

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

Tucker

Briskey

Scanlan

et al. 2015

Free Radical Biology and Medicine

Self Cite

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“…These adaptations are clinically relevant. Notably, guidelines for prescribing PRT across the chronic kidney disease continuum have been included within a recent position statement [51] , and we have recently indicated a need to update clinical practice guidelines to inform clinicians on the benefits of PRT in ESRD [52] .…”

Section: Summary and Recommendationsmentioning

confidence: 99%

Progressive Resistance Training in End-Stage Renal Disease: Systematic Review

Chan¹,

Cheema²

2016

Am J Nephrol

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Background: This systematic review provides an overview of the extant literature on progressive resistance training (PRT) in patients with end-stage renal disease (ESRD) and outlines recommendations for future trials. Methods: A systematic review of all published literature evaluating the chronic (>6 weeks) application of PRT in patients with ESRD using electronic databases. Results: The search yielded 16 clinical trials, including 11 randomized controlled trials (RCT), 4 uncontrolled trials and one trial involving a within-subjects control period plus RCT. RCT quality, assessed via the CONSORT statement, ranged from low (4/10) to high (10/10) with a mean score of 7.3/10; 7/11 RCT had a quality score ≥7.5. All trials evaluated chronic adaptation to PRT across a range of important outcomes. PRT can induce muscle hypertrophy and improve aspects of physical functioning and health-related quality of life in ESRD. There is preliminary evidence that PRT may reduce protein-energy malnutrition and cardiovascular disease risk factors, including C-reactive protein, total cholesterol, triglyceride, and measures of insulin resistance in patients with or at-risk of comorbid type 2 diabetes. The evidence base for PRT adapting some of the endpoints investigated to date remains inconsistent (e.g. physical performance tests, obesity outcomes), and many other pertinent clinical outcomes remain to be investigated. Conclusion: RCT are required to investigate a range of novel research questions related to the benefits and application of PRT in this cohort and its patient subgroups (e.g. diabetes, depression, dyslipidemia, etc.). Future studies must be of high methodological quality to inform clinical practice guidelines.

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“…Studies have shown the importance of lifestyle modification as an intradialytic PA program and as an adjuvant in CKD treatment [21]. There are several studies evaluating PA in CKD; others reporting CI observed in these patients.…”

Section: Introductionmentioning

confidence: 99%

Influence of Intradialytic Aerobic Training in Cerebral Blood Flow and Cognitive Function in Patients with Chronic Kidney Disease: A Pilot Randomized Controlled Trial

Belik

Silva

Braga

et al. 2018

Nephron

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Background and Objectives: Changes in cerebral blood flow may play an important role in cognitive impairment among hemodialysis (HD) patients. Physical activity has a promising role in delaying cognitive impairment in general population, but there are only a few studies in HD to confirm this finding. We aimed to evaluate the effects of intradialytic aerobic training on cerebral blood flow and cognitive impairment in HD. Design, Setting, Participants, and Measurements: This is a pilot, controlled, randomized trial. Fifteen patients underwent intradialytic aerobic training 3 times a week for 4 months. The control group was comprised of another 15 patients. Results: Trained patients had a statistically significant improvement of cognitive impairment and basilar maximum blood flow velocity. The proportion of arteries with increased flow velocity was statistically significant between groups. Conclusions: Intradialytic aerobic training improves cognitive impairment and cerebral blood flow of patients in HD, suggesting a possible mechanism improving cognitive impairment by physical training in HD. These data still need to be confirmed by major trials.

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Exercise & Sports Science Australia (ESSA) position statement on exercise and chronic kidney disease

Cited by 132 publications

References 44 publications

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

Progressive Resistance Training in End-Stage Renal Disease: Systematic Review

Influence of Intradialytic Aerobic Training in Cerebral Blood Flow and Cognitive Function in Patients with Chronic Kidney Disease: A Pilot Randomized Controlled Trial

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