Exercise and Air-Travel–Induced Alterations in Blood Hemostasis

Kupchak, Brian R.

doi:10.1055/s-0038-1670640

Cited by 6 publications

(6 citation statements)

References 102 publications

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“…Следовательно, любые рекомендации по допустимости авиапутешествия пока должны быть выведены из наземных исследований этого риска. Есть несколько публикаций, позволяющий сделать вывод о том, что, по всей видимости, можно установить предел безопасности приёма антагонистов витамина К в МНО, равного 4 [6,23,27]. При этом первостепенное значение при исследовании пациента, особенно принимающего пероральные антикоагулянты прямого действия (дабигатран, ривароксабан, апиксабан и т.…”

Section: оценка пригодности к авиапутешествию при тахи-и брадиаритмияхunclassified

“…В рис. 1 приведён разработанный нами алгоритм оценки пациентов с аритмиями на основе обобщения мнений экспертов [6,8,9,22,23,27,28], связанный также и с остальными аспектами, помимо кровотечений. Дополнением к рисунку является табл.…”

Section: рис 2 алгоритм оценки пациента после хирургического лечения ...unclassified

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Evaluation of opportunity for air traveling of patients with cardiac arrhythmias

Posokhov,

Praskurnichii

2023

Vestnik aritmologii

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The increasing use of air transport by people with cardiovascular diseases, prone to problems associated with air travel, and require more attention during the entire journey. Considerations for preventing the worsening of the condition of patients during air travel based on the available data are summarised, algorithms for preliminary risk assessment and preparation of patients with cardiac arrhythmias are given.

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Section: оценка пригодности к авиапутешествию при тахи-и брадиаритмияхunclassified

Section: рис 2 алгоритм оценки пациента после хирургического лечения ...unclassified

Evaluation of opportunity for air traveling of patients with cardiac arrhythmias

Posokhov,

Praskurnichii

2023

Vestnik aritmologii

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“…88 Additionally, flight-specific factors, including the hypobaric and hypoxic nature of air travel, may result in activation of the coagulation system. 89,90 When combined with hypercoagulability (dehydration) and prior trauma to the vessel wall (possibly through sporting injuries), an increased risk for VTE may be present when undertaking long-haul travel.…”

Section: Long-haul Travel and Immobilizationmentioning

confidence: 99%

Acquired and Genetic Thrombotic Risk Factors in the Athlete

Zadow

Adams

Kitic

et al. 2018

Semin Thromb Hemost

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While athletes are often considered the epitome of health due to their physique and lowered potential for metabolic and cardiovascular diseases, they may also be at risk for the onset and development of venous thromboembolism (VTE). In an attempt to achieve and remain competitive, athletes are frequently exposed to numerous athlete-specific risk factors, which may predispose them to VTE through the disruption of factors associated with Virchow's triad (i.e., hypercoagulability, venous stasis, and vessel wall injury). Indeed, hypercoagulability within an athletic population has been well documented to occur due to a combination of multiple factors including exercise, dehydration, and polycythemia. Furthermore, venous stasis within an athletic population may occur as a direct result of prolonged periods of immobilization experienced when undertaking long-distance travels for training and competition, recovery from injury, and overdevelopment of musculature. While all components of Virchow's triad are disrupted, injury to the vessel wall has emerged as the most important factor contributing to thrombosis formation within an athletic population, due to its ability to influence multiple hemostatic mechanisms. Vessel wall injury within an athletic population is often related to repetitive microtrauma to the venous and arterial walls as a direct result of sport-dependent trauma, in addition to high metabolic rates and repetitive blood monitoring. Although disturbances to Virchow's triad may not be detrimental to most individuals, approximately 1 in 1,000 athletes will experience a potentially fatal post-exercise thrombotic incidence. When acquired factors are considered in conjunction with genetic predispositions to hypercoagulability present in some athletes, an overall increased risk for VTE is present.

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“…1 Air travel has been associated with high‐risk cardiovascular events through a range of mechanisms including increased cardiopulmonary stress, perturbations of autonomic function, and induced alterations in blood hemostasis. 2 , 3 , 4 , 5 , 6 For individuals who sustain an out‐of‐hospital cardiac arrest (OHCA) successful resuscitation requires an integrated chain of actions including early arrest recognition, timely cardiopulmonary resuscitation (CPR), and defibrillation, expert advanced life support and post‐resuscitation care. 7 Air travel is distinguished by circumstances which could impact resuscitation outcome.…”

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confidence: 99%

Incidence, Mechanism, and Outcomes of On‐Plane Versus Off‐Plane Cardiac Arrest in Air Travelers

Chatterjee

Kume

Drucker

et al. 2021

JAHA

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Background Air travel affords an opportunity to evaluate resuscitation performance and outcome in a setting where automated external defibrillators (AEDs) are readily available. Methods and Results The study cohort included people aged ≥18 years with out of hospital cardiac arrest (OHCA) traveling through Seattle‐Tacoma International Airport between January 1, 2004 and December 31, 2019 treated by emergency medical services (EMS). The primary outcomes were pre‐EMS therapies (cardiopulmonary resuscitation, application of AED), return of spontaneous circulation, and survival to hospital discharge. Over the 16‐year study period, there were 143 OHCA occurring before EMS arrival, 34 (24%) on‐plane and 109 (76%) off‐plane. Cardiac etiology (81%) was the most common mechanism of arrest. The majority of arrests were bystander‐witnessed and presented with a shockable rhythm; these characteristics were more common in off‐plane OHCA compared with on‐plane (witnessed: 89% versus 74% and shockable: 72% versus 50%). Pre‐EMS therapies including cardiopulmonary resuscitation and AED application were common regardless of arrest location. Compared with on‐plane OHCA, off‐plane OHCA was associated with greater rates of return of spontaneous circulation (68% versus 44%) and 3‐fold higher rate of survival to hospital discharge (44% versus 15%). All survivors of on‐plane OHCA had AED application with defibrillation before EMS arrival. Conclusions When applied to air travel volumes, we estimate 350 air travel‐associated OHCA occur in the United States and 2000 OHCA worldwide each year, nearly a quarter of which happen on‐plane. These events are survivable when early arrest interventions including rapid arrest recognition, AED application, and CPR are deployed.

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Exercise and Air-Travel–Induced Alterations in Blood Hemostasis

Cited by 6 publications

References 102 publications

Evaluation of opportunity for air traveling of patients with cardiac arrhythmias

Evaluation of opportunity for air traveling of patients with cardiac arrhythmias

Acquired and Genetic Thrombotic Risk Factors in the Athlete

Incidence, Mechanism, and Outcomes of On‐Plane Versus Off‐Plane Cardiac Arrest in Air Travelers

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