Exercise and Bone Health

Singh, Maria A. Fiatarone

doi:10.1007/978-1-4939-2001-3_31

Cited by 4 publications

(3 citation statements)

References 193 publications

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“…[ 12 ] Doing physical activity causes the postponement of aging and disability, increased physical stamina, reduced risk of falling in the elderly,[ 13 ] reduced vasomotor symptoms arising from menopause,[ 14 ] reduced risk of cardiovascular diseases, diabetes, osteoporosis, cancer, and obesity. [ 15 16 17 ]…”

Section: Introductionmentioning

confidence: 99%

Determinants of physical activity in middle-aged woman in Isfahan using the health belief model

Hosseini

Moradi

Kazemi

et al. 2017

J Edu Health Promot

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INTRODUCTION:Nowadays with respect to the automation of the lifestyle, immobility statistics in middle-aged women has increased and they are at risk for complications of immobility. One of the models used to identify factors associated with physical activity is Health Belief Model utilized in different age and different cultural backgrounds and different results have been obtained from those studies. The purpose of this study was to investigate the factors affecting on physical activity in middle-aged women using Health Belief Model.MATERIALS AND METHODS:This descriptive-correlation study was conducted on 224 middle-aged women referring to health centers in Isfahan. Health Belief Model structures including perceived susceptibility and severity, perceived barriers and benefits, and self-efficacy were measured by questionnaire and physical activity was assessed using the international physical activity questionnaire. Collected data were analyzed using descriptive statistics and Pearson correlation coefficient test and regression analysis.RESULTS:There wasn’t significant correlation between perceived susceptibility (P = 0.263, r = 0.075) and perceived severity with physical activity duration (P = 0.127, r = 0.058) but there was positive and weak correlation between physical activity duration with perceived benefits (P = 0.001 and r = 0.26) and perceived self-efficacy (P = 0.001, r = 0.54) and had weak and inverse correlation with perceived barriers (P = 0.001, r = -0.25). Regression analysis also showed that from among all the Health Belief Model structures just self-efficacy structure has influenced on behavior independently and other structures are affected by it.CONCLUSION:The obtained results implied on a correlation between benefits, barriers and perceived self-efficacy with and moderate physical activity. Therefore it is necessary to develop appropriate educational programs with emphasis on structures of Health Belief Model that has the maximum impact on physical activity in middle-aged women.

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Section: Introductionmentioning

confidence: 99%

Determinants of physical activity in middle-aged woman in Isfahan using the health belief model

Hosseini

Moradi

Kazemi

et al. 2017

J Edu Health Promot

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“…The structural remodeled bone is the result of the constant deposition and reabsorption of the bone matrix by osteoblasts and osteoclasts, respectively. It is known that weight bearing loads applied through daily routines, such as walking or exercising drives this phenomenon, which is termed Wolff 's Law [48][49][50].…”

Section: Biology Of Bone Vascularaturementioning

confidence: 99%

Microengineered platforms for co-cultured mesenchymal stem cells towards vascularized bone tissue engineering

Park

Lim

Sung

et al. 2016

Tissue Eng Regen Med

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Bone defects are common disease requiring thorough treatments since the bone is a complex vascularized tissue that is composed of multiple cell types embedded within an intricate extracellular matrix (ECM). For past decades, tissue engineering using cells, proteins, and scaffolds has been suggested as one of the promising approaches for effective bone regeneration. Recently, many researchers have been interested in designing effective platform for tissue regeneration by orchestrating factors involved in microenvironment around tissues. Among factors affecting bone formation, vascularization during bone development and after minor insults via endochondral and intramembranous ossification is especially critical for the long-term support for functional bone. In order to create vascularized bone constructs, the interactions between human mesenchymal stem cells (MSCs) and endothelial cells (ECs) have been investigated using both direct and indirect co-culture studies. Recently, various culture methods including micropatterning techniques, three dimensional scaffolds, and microfluidics have been developed to create micro-engineered platforms that mimic the nature of vascularized bone formation, leading to the creation of functional bone structures. This review focuses on MSCs co-cultured with endothelial cells and microengineered platforms to determine the underlying interplay between co-cultured MSCs and vascularized bone constructs, which is ultimately necessary for adequate regeneration of bone defects.

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“…However, the mechanical control of modelling and remodelling processes-collectively referred to as bone (re)modelling-can be altered by ageing, bone diseases or orthopaedic manipulations like implant insertion. There are clinical cues that aged and osteoporotic bone is less responsive to loading than younger healthy bone [11,12]. Furthermore, the knowledge about the regulation of bone formation and resorption by mechanical strains around implants is very limited, thus hampering the development of effective loading protocols to prevent implant loosening.…”

Section: Introductionmentioning

confidence: 99%

Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone

Betts

Kuhn

et al. 2019

J. R. Soc. Interface.

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Although mechanical stimulation is considered a promising approach to accelerate implant integration, our understanding of load-driven bone formation and resorption around implants is still limited. This lack of knowledge may delay the development of effective loading protocols to prevent implant loosening, especially in osteoporosis. In healthy bone, formation and resorption are mechanoregulated processes. In the intricate context of peri-implant bone regeneration, it is not clear whether bone (re)modelling can still be load-driven. Here, we investigated the mechanical control of peri-implant bone (re)modelling with a well-controlled mechanobiological experiment. We applied cyclic mechanical loading after implant insertion in tail vertebrae of oestrogen depleted mice and we monitored peri-implant bone response by in vivo micro-CT. Experimental data were combined with micro-finite element simulations to estimate local tissue strains in (re)modelling locations. We demonstrated that a substantial increase in bone mass around the implant could be obtained by loading the entire bone. This augmentation could be attributed to a large reduction in bone resorption rather than to an increase in bone formation. We also showed that following implantation, mechanical regulation of bone (re)modelling was transiently lost. Our findings should help to clarify the role of mechanical stimulation on the maintenance of peri-implant bone mass.royalsocietypublishing.org/journal/rsif J. R. Soc. Interface 16: 20180667

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Exercise and Bone Health

Cited by 4 publications

References 193 publications

Determinants of physical activity in middle-aged woman in Isfahan using the health belief model

Determinants of physical activity in middle-aged woman in Isfahan using the health belief model

Microengineered platforms for co-cultured mesenchymal stem cells towards vascularized bone tissue engineering

Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone

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