2006
DOI: 10.1183/09059180.00010004
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Exercise and dyspnoea in COPD

Abstract: Dyspnoea provoked either by exercise or during a disease exacerbation is one of the most feared symptoms of the chronic obstructive pulmonary disease (COPD) patient. It contributes to impaired quality of life and patients who are more limited by exertional dyspnoea are more likely to die. The physiological mechanisms responsible for these two outcomes vary in different settings, but in both situations, changes in the resting lung volume and increased activation of the respiratory muscles relative to their maxi… Show more

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Cited by 12 publications
(9 citation statements)
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“…COPD is specifically associated with increased respiratory work (41) and skeletal neuromuscular weakness [13] . Such mechanisms can perpetuate a viscous cycle of functional decline (for review see [14] ). Experimental elevation of the perception of breathing effort/work can be reproduced via external resistive or elastic loads [15] by volitional hyperpnoea [16] , or neuromuscular blockade [17] .…”
Section: Introductionmentioning
confidence: 99%
“…COPD is specifically associated with increased respiratory work (41) and skeletal neuromuscular weakness [13] . Such mechanisms can perpetuate a viscous cycle of functional decline (for review see [14] ). Experimental elevation of the perception of breathing effort/work can be reproduced via external resistive or elastic loads [15] by volitional hyperpnoea [16] , or neuromuscular blockade [17] .…”
Section: Introductionmentioning
confidence: 99%
“…Whilst it is accepted that limitations exist in the current methodology and techniques available to evaluate the impact of in-exercise airflow limitation [34], it seems possible that changes in maximum expiratory flow volume during exercise may influence airflow and the perception of dyspnoea experienced by athletes with EIB, as they adopt ventilatory strategies to overcome this constraint.…”
Section: Exercise Airflow Limitationmentioning
confidence: 99%
“…Generalisability of our data is limited by the small sample, comprised predominantly of patients with very severe COPD who were willing to accept daily home-based assessments. Physiological evaluation of exacerbation recovery is notoriously challenging to conduct due to patient reluctance to attend repeated clinical assessments and perform forced respiratory manoeuvres during recovery [ 19 ]. Unlike previous studies, which have missing data and comparable sample sizes [ 13 , 14 ], we mitigated loss to follow-up by using home-based assessments and achieved 100% adherence to EMG para measurement.…”
mentioning
confidence: 99%